Sheianov G G, Guliaev V A
Arkh Patol. 1978;40(7):40-5.
For investigation of postirradiation reactions, of pancreatic insular cells, male Wistar rats were subjected to 1.5, 3, 7, and 15 kR of Co60 gamma-radiation. It was found that after application of doses of 7 kR or higher, interphase death of all the insular A-cells occurred within 6 hours. The cell death was demonstrated to be characterized by chromatin pycnosis, dilatation of the endoplasmic reticulum and perinuclear space, mitochondrial swelling, and desintegration of A-granules. Macrophages took no part in resorption of the dead cells. A-cell necrosis was not accompanied by morphologically observable changes in acinar cells or insucar B-cells. Some possible explanations of the more pronounced radiosensitivity of A-cells are discussed.
为了研究胰腺胰岛细胞的辐射后反应，对雄性Wistar大鼠进行了1.5、3、7和15千伦琴的钴60γ射线照射。结果发现，在给予7千伦琴或更高剂量后，所有胰岛A细胞在6小时内发生间期死亡。细胞死亡的特征表现为染色质固缩、内质网和核周间隙扩张、线粒体肿胀以及A颗粒解体。巨噬细胞未参与死亡细胞的吸收过程。A细胞坏死并未伴有腺泡细胞或胰岛B细胞在形态学上可观察到的变化。文中讨论了A细胞放射敏感性更高的一些可能解释。
