Kolomiĭtseva I K, Novoselova E G, Kulagina T P, Potekhina N I, Kaznacheev Iu S
Radiobiologiia. 1986 May-Jun;26(3):313-7.
Irradiation of animals with doses eliciting interphase death of 50-80% of cells activates lipogenesis and decreases the cholesterol content of cells. Cholesterol synthesis is activated after irradiation with doses causing death of 50% of cells: a further increase in radiation dose decreases the cholesterol synthesis. It is assumed that as membranes are destructed by radiation the adaptive lipogenesis activated to restore them.
用能使50 - 80%的细胞发生间期死亡的剂量照射动物,会激活脂肪生成并降低细胞的胆固醇含量。用能导致50%的细胞死亡的剂量照射后,胆固醇合成被激活:辐射剂量进一步增加会降低胆固醇合成。据推测,随着细胞膜被辐射破坏,适应性脂肪生成被激活以修复它们。