Department of Surgery, School of Veterinary Medicine and Animal Science, University of São Paulo, Av. Prof. Dr. Orlando Marques de Paiva, 87. Cidade Universitária, São Paulo, SP, CEP: 05508-270, Brazil.
Department of Internal Medicine, School of Veterinary Medicine and Animal Science, University of São Paulo, Av. Prof. Dr. Orlando Marques de Paiva, 87. Cidade Universitária, São Paulo, SP, CEP: 05508-270, Brazil.
BMC Vet Res. 2022 Jun 9;18(1):215. doi: 10.1186/s12917-022-03323-3.
BACKGROUND: Combined chondroitin sulfate (CS) and glucosamine (GlcN) has been widely used in oral formulations to prevent and treat osteoarthritis. CS is effective for controlling pain in osteoarthritic patients, whereas GlcN can stimulate glycosaminoglycan synthesis, thus reducing extracellular matrix degradation. Although several studies have been published on this topic, the effectiveness of treatment with oral CS and GlcN remains uncertain. The objective of this study was to analyze the progression of experimentally induced osteoarthritis in horses and verify the effectiveness of an oral compound based on CS and GlcN to treat and/or modulate this disease. The study analyzed the metacarpophalangeal joint of the left thoracic limb of 16 horses divided into two groups, with eight horses treated with CS and GlcN in the treated group (GT) and eight untreated horses in the control group (GC). Chondral lesions were induced through arthroscopy, which was defined as time-point zero (T0). Physical, ultrasonographic, and radiographic examinations and synovial fluid biomarkers measurements were performed on days 0, 30, 60, 90, and 120. At the end of the experiment (T4), arthroscopy was performed again to macroscopically evaluate the joints and collect material for microscopic analysis. RESULTS: Significant differences were observed between groups in some evaluated parameters, such as visual lameness assessment, synovial concentrations of prostaglandin E2, and ultrasound examination. However, the GT still presented slightly improved results for joint flexion angle, analysis of lameness using sensors, and histopathological analysis of chondral repair tissue, however, without the statistical significance (p>0.05). CONCLUSIONS: The treatment was considered effective in the clinical modulation of experimental osteoarthritis, with improvement of some parameters in the GT. However, this type of treatment may not be entirely effective to change the catabolic process in articular cartilage and the progressive induced chondral damage.
背景：联合硫酸软骨素（CS）和氨基葡萄糖（GlcN）已广泛用于口服制剂，以预防和治疗骨关节炎。CS 可有效控制骨关节炎患者的疼痛，而 GlcN 可刺激糖胺聚糖合成，从而减少细胞外基质降解。尽管已经发表了几项关于这个主题的研究，但口服 CS 和 GlcN 治疗的有效性仍不确定。本研究的目的是分析实验诱导的马骨关节炎的进展，并验证基于 CS 和 GlcN 的口服复合物治疗和/或调节这种疾病的有效性。该研究分析了 16 匹马左前肢掌指关节，分为两组，8 匹马在治疗组（GT）中接受 CS 和 GlcN 治疗，8 匹马在对照组（GC）中未接受治疗。通过关节镜检查诱导软骨病变，定义为时间点零（T0）。在第 0、30、60、90 和 120 天进行物理、超声和放射学检查以及滑液生物标志物测量。在实验结束时（T4），再次进行关节镜检查以宏观评估关节并收集用于微观分析的材料。 结果：在一些评估参数中，如视觉跛行评估、滑膜前列腺素 E2 浓度和超声检查，两组之间存在显著差异。然而，GT 仍在关节弯曲角度、传感器跛行分析和软骨修复组织的组织病理学分析方面表现出略微改善的结果，但无统计学意义（p>0.05）。 结论：该治疗被认为对实验性骨关节炎的临床调节有效，GT 中的一些参数有所改善。然而，这种治疗类型可能不完全有效改变关节软骨的分解代谢过程和诱导的进行性软骨损伤。
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