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硫酸软骨素和葡萄糖胺治疗兔颞下颌关节骨关节炎严重程度的降低。

Reduction of osteoarthritis severity in the temporomandibular joint of rabbits treated with chondroitin sulfate and glucosamine.

机构信息

School of Dentistry/Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul, Brazil.

Oral and Maxillofacial Surgery Unit/ Clinical Hospital of Porto Alegre (HCPA), School of Dentistry/Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul, Brazil.

出版信息

PLoS One. 2020 Apr 15;15(4):e0231734. doi: 10.1371/journal.pone.0231734. eCollection 2020.

DOI:10.1371/journal.pone.0231734
PMID:32294140
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7159193/
Abstract

Osteoarthritis is a degenerative disease that causes substantial changes in joint tissues, such as cartilage degeneration and subchondral bone sclerosis. Chondroitin sulfate and glucosamine are commonly used products for the symptomatic treatment of osteoarthritis. The aim of the present study was to investigate the effects of these products when used as structure-modifying drugs on the progression of osteoarthritis in the rabbit temporomandibular joint. Thirty-six New Zealand rabbits were divided into 3 groups (n = 12/group): control (no disease); osteoarthritis (disease induction); and treatment (disease induction and administration of chondroitin sulfate and glucosamine). Osteoarthritis was induced by intra-articular injection of monosodium iodoacetate. Animals were killed at 30 and 90 days after initiation of therapy. The treatment was effective in reducing disease severity, with late effects and changes in the concentration of glycosaminoglycans in the articular disc. The results indicate that chondroitin sulfate and glucosamine may have a structure-modifying effect on the tissues of rabbit temporomandibular joints altered by osteoarthritis.

摘要

骨关节炎是一种退行性疾病，会导致关节组织发生实质性变化，如软骨退化和软骨下骨硬化。硫酸软骨素和氨基葡萄糖是常用于治疗骨关节炎症状的产品。本研究旨在探讨这些产品作为结构修饰药物对兔颞下颌关节骨关节炎进展的影响。36 只新西兰兔被分为 3 组（每组 n = 12）：对照组（无疾病）；骨关节炎组（疾病诱导）；治疗组（疾病诱导和硫酸软骨素与氨基葡萄糖给药）。通过关节内注射单碘乙酸钠诱导骨关节炎。在治疗开始后 30 和 90 天处死动物。治疗组能有效减轻疾病严重程度，对关节盘中糖胺聚糖的浓度也有迟发作用和改变。结果表明，硫酸软骨素和氨基葡萄糖可能对骨关节炎改变的兔颞下颌关节组织具有结构修饰作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67db/7159193/a72a84c8e3be/pone.0231734.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67db/7159193/30140072483f/pone.0231734.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67db/7159193/0c754b02f2bc/pone.0231734.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67db/7159193/f616322dcffe/pone.0231734.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67db/7159193/2f668e1d5e05/pone.0231734.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67db/7159193/a72a84c8e3be/pone.0231734.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67db/7159193/30140072483f/pone.0231734.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67db/7159193/0c754b02f2bc/pone.0231734.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67db/7159193/f616322dcffe/pone.0231734.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67db/7159193/2f668e1d5e05/pone.0231734.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67db/7159193/a72a84c8e3be/pone.0231734.g005.jpg

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[1]
Reduction of osteoarthritis severity in the temporomandibular joint of rabbits treated with chondroitin sulfate and glucosamine.

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[4]
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[10]
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引用本文的文献

[1]
Exploring the mechanism of chondroitin sulfate-selenium nanoparticles in improving Alzheimer's disease: Insights from intestinal flora evaluation.

Heliyon. 2024-9-28

[2]
Unveiling MRI-based structural phenotypes in temporomandibular joint osteoarthritis: implications for clinical practice and research.

Dental Press J Orthod. 2024

[3]
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Bioengineering (Basel). 2024-4-27

[4]
Effects of oral treatment with chondroitin sulfate and glucosamine in an experimental model of metacarpophalangeal osteoarthritis in horses.

BMC Vet Res. 2022-6-9

[5]
Is Extracellular Vesicle-Based Therapy the Next Answer for Cartilage Regeneration?

Front Bioeng Biotechnol. 2021-4-23

[6]
Mesenchymal stem cells in osteoarthritis therapy: a review.

Am J Transl Res. 2021-2-15

[7]
Evolution of mirror-image pain in temporomandibular joint osteoarthritis mouse model.

J Appl Oral Sci. 2021

本文引用的文献

[1]
Condylotomy to Reverse Temporomandibular Joint Osteoarthritis in Rabbits.

J Oral Maxillofac Surg. 2019-11

[2]
Effect of platelet-rich plasma on temporomandibular joint cartilage wound healing: Experimental study in rabbits.

J Craniomaxillofac Surg. 2018-12-13

[3]
Current status of top 10 nutraceuticals used for Knee Osteoarthritis in India.

J Clin Orthop Trauma. 2018

[4]
Part I: Development and Physiology of the Temporomandibular Joint.

Curr Osteoporos Rep. 2018-8

[5]
The effect of sodium hyaluronate-chondroitin sulfate combined solution on cartilage formation in osteochondral defects of the rabbit knee: an experimental study.

Ther Clin Risk Manag. 2017-4-18

[6]
Systematic Analysis of Pharmaceutical Preparations of Chondroitin Sulfate Combined with Glucosamine.

Pharmaceuticals (Basel). 2017-4-1

[7]
Glucosamine and chondroitin for the treatment of osteoarthritis.

World J Orthop. 2017-1-18

[8]
Topographical and depth-dependent glycosaminoglycan concentration in canine medial tibial cartilage 3 weeks after anterior cruciate ligament transection surgery-a microscopic imaging study.

Quant Imaging Med Surg. 2016-12

[9]
The combined therapy with chondroitin sulfate plus glucosamine sulfate or chondroitin sulfate plus glucosamine hydrochloride does not improve joint damage in an experimental model of knee osteoarthritis in rabbits.

Eur J Pharmacol. 2016-11-12

[10]
Chondroprotective effects of the combination chondroitin sulfate-glucosamine in a model of osteoarthritis induced by anterior cruciate ligament transection in ovariectomised rats.

Biomed Pharmacother. 2016-4

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