Eberhart R C, Dengle S K, Curtis R M
Artif Organs. 1978 Feb;2(1):19-34. doi: 10.1111/j.1525-1594.1978.tb00999.x.
Three categories of membrane oxygenators are considered: passive flow, secondary flow induced by the mainstream, secondary flow induced by an external application of energy. The current status of mathematical methods for analysis of fluid mechanics, O2 and CO2 exchange for these categories are briefly reviewed. Emphasis is given to approximate methods for calculation of gas exchange. Practical methods for experimental design optimization studies are outlined; these methods are extended to evaluation of O2 and CO2 exchange in clinical operation. A new method for estimation of internal ventilation and perfusion maldistribution and diffusion resistance is described. A brief assessment of blood damage in clinical application of the oxygenator is presented from the point of view of deterioration of gas exchange performance.
被动流、由主流诱导的二次流、由外部能量施加诱导的二次流。简要回顾了用于分析这些类型的流体力学、氧气和二氧化碳交换的数学方法的现状。重点介绍了气体交换计算的近似方法。概述了实验设计优化研究的实用方法；这些方法被扩展到临床操作中氧气和二氧化碳交换的评估。描述了一种估计内部通气和灌注分布不均以及扩散阻力的新方法。从气体交换性能恶化的角度对氧合器临床应用中的血液损伤进行了简要评估。
