Laboratory of Tumor Immunology and Cell Therapy, Department of Experimental Medicine, "Sapienza" University of Rome, Viale Regina Elena 324, 00161 Rome, Italy.
Department of Neurology and Psychiatry, Neurosurgery, "Sapienza" University of Rome, Viale dell' Università 30, 00185 Rome, Italy.
Int J Mol Sci. 2022 Jun 5;23(11):6312. doi: 10.3390/ijms23116312.
Despite diagnostic and therapeutic improvements, glioblastoma (GB) remains one of the most threatening brain tumor in adults, underlining the urgent need of new therapeutic targets. Lectins are glycan-binding proteins that regulate several biological processes through the recognition of specific sugar motifs. Lectins and their ligands are found on immune cells, endothelial cells and, also, tumor cells, pointing out a strong correlation among immunity, tumor microenvironment and vascularization. In GB, altered glycans and lectins contribute to tumor progression and immune evasion, shaping the tumor-immune landscape promoting immunosuppressive cell subsets, such as myeloid-derived suppressor cells (MDSCs) and M2-macrophages, and affecting immunoeffector populations, such as CD8 T cells and dendritic cells (DCs). Here, we discuss the latest knowledge on the immune cells, immune related lectin receptors (C-type lectins, Siglecs, galectins) and changes in glycosylation that are involved in immunosuppressive mechanisms in GB, highlighting their interest as possible novel therapeutical targets.
尽管在诊断和治疗方面取得了进展，但胶质母细胞瘤（GB）仍然是成年人中最具威胁性的脑肿瘤之一，这凸显了寻找新治疗靶点的迫切需求。凝集素是糖结合蛋白，通过识别特定的糖基模式来调节多种生物过程。凝集素及其配体存在于免疫细胞、内皮细胞和肿瘤细胞上，这表明免疫、肿瘤微环境和血管生成之间存在很强的相关性。在 GB 中，糖基和凝集素的改变有助于肿瘤的进展和免疫逃逸，形成促进免疫抑制细胞亚群（如髓系来源的抑制细胞（MDSCs）和 M2 巨噬细胞）和影响免疫效应细胞群（如 CD8 T 细胞和树突状细胞（DCs））的肿瘤免疫景观。在这里，我们讨论了关于参与 GB 中免疫抑制机制的免疫细胞、免疫相关凝集素受体（C 型凝集素、Siglecs、半乳糖凝集素）和糖基化改变的最新知识，强调了它们作为潜在新治疗靶点的意义。
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