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用于内耳疾病的纳米材料:挑战、局限与机遇

Nanomaterials for Inner Ear Diseases: Challenges, Limitations and Opportunities.

作者信息

Li Liling, Luo Jia, Lin Xuexin, Tan Jingqian, Li Peng

机构信息

Department of Otolaryngology Head and Neck Surgery, The Third Affiliated Hospital of Sun Yat-sen University, No.600 Tianhe Road, Guangzhou 510630, China.

Department of Otolaryngology Head and Neck Surgery, The Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen 518033, China.

出版信息

Materials (Basel). 2022 May 25;15(11):3780. doi: 10.3390/ma15113780.

Abstract

The inner ear is located deep in the temporal bone and has a complex anatomy. It is difficult to observe and obtain pathological tissues directly. Therefore, the diagnosis and treatment of inner ear diseases have always been a major clinical problem. The onset of inner ear disease can be accompanied by symptoms such as hearing loss, dizziness and tinnitus, which seriously affect people's lives. Nanoparticles have the characteristics of small size, high bioavailability and strong plasticity. With the development of related research on nanoparticles in inner ear diseases, nanoparticles have gradually become a research hotspot in inner ear diseases. This review briefly summarizes the research progress, opportunities and challenges of the application of nanoparticles in inner ear diseases.

摘要

内耳位于颞骨深处,解剖结构复杂。直接观察和获取病理组织很困难。因此,内耳疾病的诊断和治疗一直是临床的一大难题。内耳疾病的发作可能伴有听力损失、头晕和耳鸣等症状,严重影响人们的生活。纳米颗粒具有尺寸小、生物利用度高和可塑性强等特点。随着纳米颗粒在内耳疾病相关研究的发展,纳米颗粒逐渐成为内耳疾病的研究热点。本文综述简要总结了纳米颗粒在内耳疾病应用中的研究进展、机遇和挑战。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f3a6/9181474/86fc87d598ee/materials-15-03780-g001.jpg

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