Bioacoustics Research Laboratory, Department of Neurosciences, University of Padova, via G. Orus, 2b, 35129 Padova, Italy.
National Interuniversity Consortium of Materials Science and Technology (INSTM), via G. Giusti 9, 50121 Firenze, Italy.
Int J Mol Sci. 2022 Feb 3;23(3):1761. doi: 10.3390/ijms23031761.
The biocompatibility and the antioxidant activity of barium titanate (BaTiO) and lithium niobate (LiNbO) were investigated on a neuronal cell line, the PC12, to explore the possibility of using piezoelectric nanoparticles in the treatment of inner ear diseases, avoiding damage to neurons, the most delicate and sensitive human cells. The cytocompatibility of the compounds was verified by analysing cell viability, cell morphology, apoptotic markers, oxidative stress and neurite outgrowth. The results showed that BaTiO and LiNbO nanoparticles do not affect the viability, morphological features, cytochrome c distribution and production of reactive oxygen species (ROS) by PC12 cells, and stimulate neurite branching. These data suggest the biocompatibility of BaTiO and LiNbO nanoparticles, and that they could be suitable candidates to improve the efficiency of new implantable hearing devices without damaging the neuronal cells.
钡钛矿（BaTiO）和铌酸锂（LiNbO）的生物相容性和抗氧化活性在神经元细胞系 PC12 上进行了研究，以探索在治疗内耳疾病时使用压电纳米粒子的可能性，避免对神经元造成损伤，神经元是最精细和敏感的人类细胞。通过分析细胞活力、细胞形态、凋亡标志物、氧化应激和神经突生长来验证化合物的细胞相容性。结果表明，BaTiO 和 LiNbO 纳米颗粒不会影响 PC12 细胞的活力、形态特征、细胞色素 c 分布和活性氧（ROS）的产生，并刺激神经突分支。这些数据表明 BaTiO 和 LiNbO 纳米颗粒具有生物相容性，它们可能是改善新型植入式听力设备效率而不损伤神经元细胞的合适候选材料。
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