Park Jin-Woo, Kim Eun-Kyoung, Lee Jiyoun, Chung Seung Hyun, Boo Gihong, Do Sang-Hwan
Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Seongnam 13620, Korea.
Department of Anesthesiology and Pain Medicine, College of Medicine, Seoul National University, Seoul 03080, Korea.
J Clin Med. 2022 May 27;11(11):3040. doi: 10.3390/jcm11113040.
Magnesium deficiency, which is known to be highly prevalent among patients with diabetes, has been associated with insulin resistance and poor glucose control. Here, we aimed to investigate the effects of intraoperative magnesium administration on postoperative glucose control in patients with diabetes. We retrospectively reviewed the medical records of patients with type 2 diabetes who had undergone total joint arthroplasty at a tertiary hospital, where intraoperative magnesium sulfate injections were frequently performed for postoperative analgesia. The patients were grouped based on whether treated with magnesium or not (magnesium vs. control groups). We investigated postoperative blood glucose levels and sliding scale insulin requirements. After propensity matching, 170 patients were allotted to each group. Both the mean glucose level and the incidence of a mean glucose level of >200mg/dL were significantly lower in the magnesium group than in the control group (p = 0.040 and 0.013, respectively). There was also a lower insulin requirement in the magnesium group (p = 0.043). Multivariate logistic regression revealed that magnesium treatment was significantly related to a less frequent incidence of a mean blood glucose level of >200 mg/dL (p = 0.047). This study demonstrated that magnesium sulfate infusion was associated with an improved postoperative blood glucose profile in patients with diabetes.
镁缺乏在糖尿病患者中极为普遍，且与胰岛素抵抗及血糖控制不佳有关。在此，我们旨在研究术中给予镁对糖尿病患者术后血糖控制的影响。我们回顾性分析了一家三级医院中接受全关节置换术的2型糖尿病患者的病历，该医院常进行术中注射硫酸镁以用于术后镇痛。根据是否接受镁治疗将患者分组（镁组与对照组）。我们调查了术后血糖水平及胰岛素追加用量。经过倾向得分匹配后，每组各分配170例患者。镁组的平均血糖水平及平均血糖水平>200mg/dL的发生率均显著低于对照组（分别为p = 0.040和0.013）。镁组的胰岛素需求量也较低（p = 0.043）。多因素逻辑回归显示，镁治疗与平均血糖水平>200 mg/dL的发生率较低显著相关（p = 0.047）。本研究表明，输注硫酸镁与改善糖尿病患者术后血糖状况有关。
