Hamarshih Mohammad, Hamshari Suha, Nazzal Zaher, Snobar Farha, Mletat Rawa, Abu-Mazen Ola, Maraqa Beesan
Consultant Family Medicine, and Diabetology, Palestine Diabetes Institute, Ramallah, Palestine.
Department of Medicine, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine.
Indian J Endocrinol Metab. 2022 Nov-Dec;26(6):575-580. doi: 10.4103/ijem.ijem_213_22. Epub 2023 Feb 7.
BACKGROUND/AIM: Hypomagnesaemia has been shown to have a significant impact on both glycaemic control and diabetes complications in type 2 diabetes mellitus (T2DM) patients. This study aims to assess the prevalence of hypomagnesaemia in T2DM patients and find the association between serum magnesium levels and outcomes relevant to glycaemic control and diabetic complications in primary care unit.
A cross-sectional study was conducted and included 373 patients (222 males and 151 females) from primary care unit. Serum magnesium levels were measured by the colorimetric endpoint method using the Cobas C501 system. Hypomagnesaemia was determined to be a serum magnesium level <1.6 mg/dL. In addition, the following data was also obtained: patients' characteristics, anthropometric measurements, smoking status, HbA1c, comorbidities and therapeutic management.
Patients' mean age was 56.2 ± 10.8 years, 24.6% were smokers, and most were overweight or obese. About 60% have a history of hypertension, and the majority have had diabetes for more than 10 years. Their mean HbA1c level was 8.5 ± 2%. The prevalence of hypomagnesaemia was 11% (95% CI: 8%-14.6%). It was found to be significantly higher among females (adjusted OR: 2.7, 95%CI: 1.2%-5.8%), patients with HbA1c ≥8% (adjusted OR: 2.4, 95%CI: 1.1%-5.5%) and patients with a history of diabetic retinopathy (adjusted OR: 2.7, 95%CI: 1.1%-7.1%).
The study showed that hypomagnesaemia is more prevalent in females and is associated with diabetic retinopathy and poor glycaemic control. Having a sufficient magnesium level may be associated with better glycaemic control and a reduced occurrence of complications.
背景/目的：低镁血症已被证明对2型糖尿病（T2DM）患者的血糖控制和糖尿病并发症均有显著影响。本研究旨在评估基层医疗单位中T2DM患者低镁血症的患病率，并找出血清镁水平与血糖控制及糖尿病并发症相关结局之间的关联。
开展了一项横断面研究，纳入了来自基层医疗单位的373例患者（222例男性和151例女性）。使用Cobas C501系统通过比色终点法测量血清镁水平。低镁血症定义为血清镁水平<1.6mg/dL。此外，还获取了以下数据：患者特征、人体测量数据、吸烟状况、糖化血红蛋白（HbA1c）、合并症及治疗管理情况。
患者的平均年龄为56.2±10.8岁，24.6%为吸烟者，大多数为超重或肥胖。约60%有高血压病史，大多数患糖尿病超过10年。他们的平均HbA1c水平为8.5±2%。低镁血症的患病率为11%（95%置信区间：8%-14.6%）。结果发现，女性（校正比值比：2.7，95%置信区间：1.2%-5.8%）、HbA1c≥8%的患者（校正比值比：2.4，95%置信区间：1.1%-5.5%）以及有糖尿病视网膜病变病史的患者（校正比值比：2.7，95%置信区间：1.1%-7.1%）中低镁血症的患病率显著更高。
该研究表明，低镁血症在女性中更为普遍，且与糖尿病视网膜病变及血糖控制不佳相关。维持充足的镁水平可能与更好的血糖控制及并发症发生率降低有关。
