几种神经系统疾病中α-突触核蛋白脑脊液水平的评估

Evaluation of Alpha-Synuclein Cerebrospinal Fluid Levels in Several Neurological Disorders.

作者信息

Agnello Luisa, Lo Sasso Bruna, Vidali Matteo, Scazzone Concetta, Gambino Caterina Maria, Piccoli Tommaso, Bivona Giulia, Ciaccio Anna Maria, Giglio Rosaria Vincenza, La Bella Vincenzo, Ciaccio Marcello

机构信息

Institute of Clinical Biochemistry, Clinical Molecular Medicine and Clinical Laboratory Medicine, Department of Biomedicine, Neurosciences and Advanced Diagnostics, University of Palermo, 90127 Palermo, Italy.

Department of Laboratory Medicine, Azienda Ospedaliera Universitaria Policlinico "P. Giaccone", 90127 Palermo, Italy.

出版信息

J Clin Med. 2022 May 31;11(11):3139. doi: 10.3390/jcm11113139.

DOI:10.3390/jcm11113139

PMID:35683523

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9181117/

Abstract

(1) Background: Alpha-synuclein (α-syn) is a presynaptic neuronal protein that regulates several neuronal functions. In recent decades, the role of α-syn as a biomarker of neurodegenerative diseases has been explored, especially in synucleinopathies. However, only a few studies have assessed its role as biomarker in other neurological disorders. The aim of the study was to evaluate cerebrospinal fluid (CSF) α-syn levels in several neurological disorders; (2) Methods: We measured CSF α-syn levels by a commercial ELISA kit in 158 patients classified in the following group: controls, Alzheimer’s Disease (AD), cerebrovascular diseases, inflammatory central nervous system diseases, other neurological diseases, Parkinson’s Disease (PD), and peripheral neuropathy; (3) Results: Patients with PD showed the lowest and patients with AD the highest levels of CSF α-syn (1372 vs. 2912 pg/mL, respectively, p < 0.001). In AD patients, α-syn levels were significantly associated with tau proteins; (4) Conclusions: α-syn could represent a biomarker of neurodegenerative diseases.

摘要

（1）背景：α-突触核蛋白（α-syn）是一种调节多种神经元功能的突触前神经元蛋白。近几十年来，人们一直在探索α-syn作为神经退行性疾病生物标志物的作用，尤其是在突触核蛋白病中。然而，只有少数研究评估了其在其他神经系统疾病中作为生物标志物的作用。本研究的目的是评估几种神经系统疾病患者脑脊液（CSF）中α-syn的水平；（2）方法：我们使用商用ELISA试剂盒测量了158例患者脑脊液中α-syn的水平，这些患者分为以下几组：对照组、阿尔茨海默病（AD）、脑血管疾病、炎症性中枢神经系统疾病、其他神经系统疾病、帕金森病（PD）和周围神经病变；（3）结果：PD患者脑脊液中α-syn水平最低，AD患者最高（分别为1372 vs. 2912 pg/mL，p < 0.001）。在AD患者中，α-syn水平与tau蛋白显著相关；（4）结论：α-syn可能是神经退行性疾病的生物标志物。