TAR DNA结合蛋白43（TDP - 43）作为肌萎缩侧索硬化症候选生物标志物的作用：一项系统评价和荟萃分析
The Role of TAR DNA Binding Protein 43 (TDP-43) as a CandiDate Biomarker of Amyotrophic Lateral Sclerosis: A Systematic Review and Meta-Analysis.
作者信息
Gambino Caterina Maria, Ciaccio Anna Maria, Lo Sasso Bruna, Giglio Rosaria Vincenza, Vidali Matteo, Agnello Luisa, Ciaccio Marcello
机构信息
Department of Biomedicine, Neurosciences and Advanced Diagnostics, Clinical Molecular Medicine and Clinical Laboratory Medicine, Institute of Clinical Biochemistry, University of Palermo, 90127 Palermo, Italy.
Department of Laboratory Medicine, University Hospital "P. Giaccone", 90127 Palermo, Italy.
出版信息
Diagnostics (Basel). 2023 Jan 23;13(3):416. doi: 10.3390/diagnostics13030416.
BACKGROUND
TAR DNA-binding protein 43 (TDP-43) aggregation in neuronal cells is recognized as a hallmark of amyotrophic lateral sclerosis (ALS). Although the literature strongly supports the pathogenetic role of TDP-43 in ALS pathogenesis, the role of TDP-43 as a biomarker of ALS is controversial. We performed a systematic review and meta-analysis to assess the diagnostic performance of TDP-43 for ALS.
METHODS
Relevant publications were identified by a systematic literature search on PubMed and Web of Science from their inception to 8 April 2022.
RESULTS
Seven studies, including 472 individuals, of whom 254 had ALS according to the Revised Amyotrophic Lateral Sclerosis Functional Rating Scale, met the inclusion criteria for our meta-analysis. According to the random-effects model, CSF TDP-43 levels are higher in ALS patients compared with control groups.
CONCLUSIONS
CSF TDP-43 could represent a biomarker of ALS, but further studies are mandatory before drawing conclusions.
背景
神经元细胞中TAR DNA结合蛋白43（TDP - 43）聚集被认为是肌萎缩侧索硬化症（ALS）的一个标志。尽管文献有力地支持了TDP - 43在ALS发病机制中的致病作用，但TDP - 43作为ALS生物标志物的作用仍存在争议。我们进行了一项系统评价和荟萃分析，以评估TDP - 43对ALS的诊断性能。
方法
通过对PubMed和Web of Science从创刊到2022年4月8日进行系统文献检索，确定相关出版物。
结果
七项研究，包括472名个体，其中根据修订的肌萎缩侧索硬化功能评定量表有254人患有ALS，符合我们荟萃分析的纳入标准。根据随机效应模型，与对照组相比，ALS患者脑脊液中TDP - 43水平更高。
结论
脑脊液TDP - 43可能代表ALS的一种生物标志物，但在得出结论之前必须进行进一步研究。
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