Zarobkiewicz Michał K, Morawska Izabela, Kowalska Wioleta, Halczuk Paweł, Roliński Jacek, Bojarska-Junak Agnieszka A
Department of Clinical Immunology, Medical University of Lublin, 20-093 Lublin, Poland.
Department of Neurology, Medical University of Lublin, 20-090 Lublin, Poland.
J Clin Med. 2022 Jun 4;11(11):3210. doi: 10.3390/jcm11113210.
. PECAM-1 and NKRP1A are both involved in the vascular transmigration of T lymphocytes. Vascular transmigration is a crucial process in multiple sclerosis pathogenesis. . The current paper presents an analysis of PECAM-1 and NKRP1A expression on γδ T cells. Expression of PECAM-1 and NKRP1A on subsets of γδ T cells was performed with flow cytometry. . Based on the flow cytometry data, PECAM1 was slightly differentially modulated on γδ T cells-it was up-regulated during relapse, but down-regulated during remission. Moreover, a significant downregulation of CD3 expression was noted on γδ T cells from MS patients, most notably during relapse. . This may be a sign of the overall activation of γδ T cells in the course of multiple sclerosis.
PECAM-1和NKRP1A都参与T淋巴细胞的血管迁移。血管迁移是多发性硬化症发病机制中的一个关键过程。本文对γδ T细胞上PECAM-1和NKRP1A的表达进行了分析。采用流式细胞术检测γδ T细胞亚群上PECAM-1和NKRP1A的表达。根据流式细胞术数据，PECAM1在γδ T细胞上的调节略有差异——在复发期间上调，但在缓解期间下调。此外，在MS患者的γδ T细胞上观察到CD3表达显著下调，最明显的是在复发期间。这可能是多发性硬化症过程中γδ T细胞整体激活的一个迹象。
