血小板内皮细胞黏附分子-1（PECAM-1）在缓解期的γδT细胞中表达下调，但在多发性硬化症复发期上调。

PECAM-1 Is Down-Regulated in γδT Cells during Remission, but Up-Regulated in Relapse of Multiple Sclerosis.

作者信息

Zarobkiewicz Michał K, Morawska Izabela, Kowalska Wioleta, Halczuk Paweł, Roliński Jacek, Bojarska-Junak Agnieszka A

机构信息

Department of Clinical Immunology, Medical University of Lublin, 20-093 Lublin, Poland.

Department of Neurology, Medical University of Lublin, 20-090 Lublin, Poland.

出版信息

J Clin Med. 2022 Jun 4;11(11):3210. doi: 10.3390/jcm11113210.

. PECAM-1 and NKRP1A are both involved in the vascular transmigration of T lymphocytes. Vascular transmigration is a crucial process in multiple sclerosis pathogenesis. . The current paper presents an analysis of PECAM-1 and NKRP1A expression on γδ T cells. Expression of PECAM-1 and NKRP1A on subsets of γδ T cells was performed with flow cytometry. . Based on the flow cytometry data, PECAM1 was slightly differentially modulated on γδ T cells-it was up-regulated during relapse, but down-regulated during remission. Moreover, a significant downregulation of CD3 expression was noted on γδ T cells from MS patients, most notably during relapse. . This may be a sign of the overall activation of γδ T cells in the course of multiple sclerosis.