Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Neurology Medical Unit, Karolinska University Hospital, Stockholm, Sweden.
Acta Neurol Scand. 2021 Jun;143(6):587-601. doi: 10.1111/ane.13411. Epub 2021 Mar 22.
Multiple sclerosis (MS) is a challenging and disabling condition, predominantly affecting individuals in their early life, and has an impact functionally, financially, and on quality of life. However, there is a lack of systematic approach towards assessing socioeconomic consequences of MS. Our objective was to systematically review observational analytical studies investigating the socioeconomic consequences of MS. We conducted a systematic review on socioeconomic consequences of MS with a focus on employment-, income-, work ability- and relationship-related outcomes between MS and the general population. Additionally, the educational characteristics were extracted. From 4958 studies identified, 187 were assessed for eligibility and a total of 27 studies from eight countries were included in this qualitative assessment; 32 different outcomes were identified. All studies indicated pronounced differences between MS patients and the general population, for example 15%-30% lower employment, lower earnings and higher social benefits, higher absenteeism and presenteeism proportions, higher work disability (eg, sick-leave days) among MS patients. Some studies also indicated differences in the family or relationship characteristics. There were no apparent differences with regard to educational level. In conclusion, socioeconomic data can serve as robust outcome measures to study various aspects of MS reflecting the broader consequences of the disease.
多发性硬化症（MS）是一种具有挑战性且使人丧失能力的疾病，主要影响处于生命早期的个体，对功能、经济和生活质量都有影响。然而，目前缺乏系统的方法来评估多发性硬化症的社会经济后果。我们的目标是系统地回顾观察性分析研究，以评估多发性硬化症的社会经济后果。我们对多发性硬化症的社会经济后果进行了系统回顾，重点关注就业、收入、工作能力和多发性硬化症与普通人群之间的关系相关结果。此外，还提取了教育特征。从确定的 4958 项研究中，评估了 187 项研究的资格，共有来自 8 个国家的 27 项研究被纳入这项定性评估；确定了 32 个不同的结果。所有研究都表明多发性硬化症患者与普通人群之间存在明显差异，例如，就业比例低 15%-30%，收入和社会福利较低，缺勤和旷工比例较高，工作能力残疾（例如，病假天数）较高。一些研究还表明家庭或关系特征存在差异。在教育水平方面没有明显差异。总之，社会经济数据可以作为研究多发性硬化症各个方面的有力结果衡量标准，反映疾病的更广泛后果。
