Quan Liang, Xin Yuan, Wu Xixi, Ao Qiang
NMPA Key Laboratory for Quality Research and Control of Tissue Regenerative Biomaterial & Institute of Regulatory Science for Medical Device & National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China.
Polymers (Basel). 2022 May 27;14(11):2184. doi: 10.3390/polym14112184.
Self-healing hydrogels and traditional hydrogels both have three-dimensional polymeric networks that are capable of absorbing and retaining a large amount of water. Self-healing hydrogels can heal and restore damage automatically, and they can avoid premature failure of hydrogels caused by mechanical damage after implantation. The formation mechanism of self-healing hydrogels and the factors that hydrogels can load are various. Researchers can design hydrogels to meet the needs of different tissues through the diversity of hydrogels Therefore, it is necessary to summarize different self-healing mechanisms and different factors to achieve different functions. Here, we briefly reviewed the hydrogels designed by researchers in recent years according to the self-healing mechanism of water coagulation. Then, the factors for different functions of self-healing hydrogels in different tissues were statistically analyzed. We hope our work can provide effective support for researchers in the design process of self-healing hydrogel.
自愈合水凝胶和传统水凝胶都具有三维聚合物网络，能够吸收和保留大量水分。自愈合水凝胶能够自动愈合和修复损伤，并且可以避免植入后因机械损伤导致水凝胶过早失效。自愈合水凝胶的形成机制以及水凝胶能够负载的因素多种多样。研究人员可以通过水凝胶的多样性来设计水凝胶，以满足不同组织的需求。因此，有必要总结不同的自愈合机制和实现不同功能的不同因素。在此，我们根据水凝固的自愈合机制简要回顾了研究人员近年来设计的水凝胶。然后，对自愈合水凝胶在不同组织中实现不同功能的因素进行了统计分析。我们希望我们的工作能够在自愈合水凝胶的设计过程中为研究人员提供有效的支持。
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