Department of Respiratory Medicine, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
Department of Neurology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
Nutrients. 2022 May 29;14(11):2282. doi: 10.3390/nu14112282.
This study aimed to evaluate the relationship between the daily dietary intake of riboflavin (DDIR) and impaired lung function associated with dibutyl phthalate (DBP) exposure. Data of 4631 adults in this national cross-sectional survey were included. Urinary mono-benzyl phthalate (MBP) was used to evaluate the level of DBP exposure. The ln-transformed urinary creatinine-corrected MBP (ln(MBP/UCr)) level was used in the statistical models. High DDIR was defined as the DDIR ≥1.8 mg per day. The results of lung function impairment and high monocytes were significantly higher in the highest MBP group compared with the lowest MBP group. A significant interaction between ln(MBP/UCr) and DDIR ( = 0.029) was detected for the risk of lung function impairment. The risk of lung function impairment (OR 1.85, 95% CI, 1.27-2.71; = 0.018) and high neutrophils (OR 1.45, 95% CI, 1.06-1.97; = 0.018) was significantly higher in the highest vs. the lowest quartile of MBP in participants with low/normal DDIR but not in in participants with high DDIR. The results of this study showed that high DDIR was associated with less lung function impairment related with DBP exposure, and the inhibiting of the neutrophil recruitment might be the potential mechanism.
本研究旨在评估核黄素（DDIR）的日常饮食摄入量与邻苯二甲酸二丁酯（DBP）暴露相关的肺功能损害之间的关系。本全国性横断面研究共纳入 4631 名成年人的数据。尿中单苄基邻苯二甲酸酯（MBP）用于评估 DBP 暴露水平。在统计模型中使用尿肌酐校正的 MBP 的自然对数值（ln(MBP/UCr)）。高 DDIR 定义为每日 DDIR≥1.8mg。与最低 MBP 组相比，最高 MBP 组的肺功能损害和高单核细胞率显著更高。ln(MBP/UCr)和 DDIR 之间存在显著的交互作用（ = 0.029），与肺功能损害的风险相关。在低/正常 DDIR 的参与者中，与最低四分位组相比，最高四分位组的肺功能损害风险（OR 1.85，95%CI，1.27-2.71； = 0.018）和高中性粒细胞率（OR 1.45，95%CI，1.06-1.97； = 0.018）显著更高，但在高 DDIR 的参与者中没有这种相关性。本研究结果表明，高 DDIR 与 DBP 暴露相关的肺功能损害减少有关，而中性粒细胞募集的抑制可能是潜在的机制。
