Fondazione Policlinico Universitario "Agostino Gemelli" IRCCS, 00168 Rome, Italy.
Nutrients. 2022 May 31;14(11):2316. doi: 10.3390/nu14112316.
The purpose of the present study was to assess the effect of a specific oral nutritional supplement among patients recovered from COVID-19 but suffering symptoms of fatigue.
This is an observational case-control study involving a sample of 66 COVID-19 survivors divided in two groups, 33 subjects in the intervention group who received the nutritional supplement and 33 subjects in the control group. The nutritional supplement received by subjects in the active group was based on amino acids; vitamin B6 and B1; and malic, succinic and citric acids. After an 8-week follow-up, the main outcomes considered were skeletal muscle index (measured by bioelectrical impedance analysis), physical performance measures (handgrip strength, one-minute chair-stand test, six-minute walking test), and quality of life (using EuroQol visual analogue scale).
All the considered areas increased significantly in the subjects receiving the active treatment with oral nutritional supplement in comparison with the baseline values. After adjusting for age, gender, and baseline values, skeletal muscle index, handgrip strength test, the one-minute chair-stand test, and six-minute walking test values were higher among participants in the treatment group compared with subjects in control group. The oral nutritional supplement significantly improved the handgrip strength; similarly, participants in the active group showed a higher improvement in skeletal muscle index, the one-minute chair-stand test, the six-minute walking test, and in quality of life.
The nutritional supplement containing nine essential amino acids plus cysteine; vitamin B6 and B1; and malic, succinic and citric acids had a positive effect on nutritional status, functional recovery, and quality of life in COVID-19 survivors still suffering from fatigue. Additional controlled clinical trials are required to corroborate these results.
本研究旨在评估特定口服营养补充剂对 COVID-19 康复但仍有疲劳症状患者的影响。
这是一项观察性病例对照研究，涉及 66 名 COVID-19 幸存者样本，分为两组，干预组 33 名受试者接受营养补充剂，对照组 33 名受试者。接受活性组受试者的营养补充剂基于氨基酸、维生素 B6 和 B1 以及苹果酸、琥珀酸和柠檬酸。在 8 周随访后，主要观察结果为骨骼肌指数（通过生物电阻抗分析测量）、身体表现测量（握力、一分钟坐站测试、六分钟步行测试）和生活质量（使用 EuroQol 视觉模拟量表）。
与基线值相比，接受口服营养补充剂的活性治疗的受试者所有考虑因素均显著增加。在调整年龄、性别和基线值后，治疗组的骨骼肌指数、握力测试、一分钟坐站测试和六分钟步行测试值均高于对照组受试者。口服营养补充剂显著改善了握力；同样，活性组参与者在骨骼肌指数、一分钟坐站测试、六分钟步行测试和生活质量方面的改善更高。
含有九种必需氨基酸加半胱氨酸、维生素 B6 和 B1 以及苹果酸、琥珀酸和柠檬酸的营养补充剂对 COVID-19 幸存者的营养状况、功能恢复和生活质量产生了积极影响。需要进行更多的对照临床试验来证实这些结果。
