Department of Dietetics and Nutrition, Robert Stempel College of Public Health and Social Work, Florida International University, Miami, FL 33199, USA.
Department of Biostatistics, Robert Stempel College of Public Health and Social Work, Florida International University, Miami, FL 33199, USA.
Nutrients. 2022 Jun 2;14(11):2336. doi: 10.3390/nu14112336.
Previous evidence suggests a potential dual impact of aging and vitamin B6 (B6) deficiency on polyunsaturated fatty acid (PUFA) metabolism; gender may influence PUFA biosynthesis. Perturbation of PUFA compositions during B6 deficiency could be linked to age-related health outcomes. However, little is known about the interrelationships between vitamin B6, PUFA, and gender in the older population. Therefore, we investigated whether gender-specific associations of B6 intake and plasma pyridoxal 5’-phosphate (PLP) concentration, respectively, with plasma PUFA concentrations and ratios (eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), arachidonic acid (AA), EPA + DHA, EPA/AA, and (EPA + DHA)/AA) existed in older adults. We further examined the relationships of adequate B6 status (PLP ≥ 20 nmol/L) with high (above median) plasma PUFA relative to deficient B6 status. This cross-sectional study analyzed 461 participants aged ≥60 years from NHANES 2003−2004. Nutrient intakes were assessed using two 24-h recalls and supplement questionnaires. PLP and PUFA concentrations were measured. Multivariate linear regression assessed the association of B6 intake and PLP with PUFA; multivariate logistic regression evaluated the relationship of adequate B6 status with high plasma PUFA, adjusting for demographic, socioeconomic, and dietary factors; physical activity; smoking; alcohol; medication; and BMI. There were interactions between gender and B6 intake on EPA (P-interaction = 0.008) and AA (P-interaction = 0.004) only, whereas no interaction existed between gender and PLP on PUFA. PLP was directly associated with EPA (β = 0.181, P = 0.002), DHA (β = 0.109, P = 0.005), EPA + DHA (β = 0.14, P = 0.002), EPA/AA (β = 0.186, P = 0.004), and (EPA + DHA)/AA (β = 0.13, P = 0.026). The odds of having high plasma EPA (adjusted (a) OR: 2.03, P = 0.049) and EPA/AA (aOR: 3.83, P < 0.0001) were greater in those with adequate B6 status compared to those with deficient B6 status. In conclusion, in US older adults, a higher PLP level was associated with a greater level of EPA, DHA, EPA + DHA, EPA/AA, and (EPA + DHA)/AA. Adequate B6 status was associated with high EPA and EPA/AA status. These findings suggest that sufficient vitamin B6 status may positively influence PUFA metabolism in older adults.
先前的证据表明，衰老和维生素 B6（B6）缺乏对多不饱和脂肪酸（PUFA）代谢可能存在潜在的双重影响；性别可能会影响 PUFA 的生物合成。B6 缺乏时 PUFA 组成的改变可能与与年龄相关的健康结果有关。然而，关于老年人中维生素 B6、PUFA 和性别之间的相互关系知之甚少。因此，我们调查了 B6 摄入量和血浆吡哆醛 5’-磷酸（PLP）浓度是否分别与老年人的血浆 PUFA 浓度和比例（二十碳五烯酸（EPA）、二十二碳六烯酸（DHA）、花生四烯酸（AA）、EPA+DHA、EPA/AA 和（EPA+DHA）/AA）存在性别特异性关联。我们进一步研究了 B6 状态充足（PLP≥20nmol/L）与 B6 状态不足（低于中位数）相比与高（高于中位数）血浆 PUFA 之间的关系。本横断面研究分析了来自 NHANES 2003-2004 的 461 名年龄≥60 岁的参与者。使用两份 24 小时回顾和补充问卷评估营养素摄入量。测量 PLP 和 PUFA 浓度。多元线性回归评估 B6 摄入量和 PLP 与 PUFA 的关联；多变量逻辑回归调整人口统计学、社会经济和饮食因素、身体活动、吸烟、饮酒、药物、BMI 后评估 B6 状态充足与高血浆 PUFA 的关系。仅在性别和 B6 摄入之间存在 EPA（P 交互=0.008）和 AA（P 交互=0.004）之间的相互作用，而性别和 PLP 之间不存在 PUFA 相互作用。PLP 与 EPA（β=0.181，P=0.002）、DHA（β=0.109，P=0.005）、EPA+DHA（β=0.14，P=0.002）、EPA/AA（β=0.186，P=0.004）和（EPA+DHA）/AA（β=0.13，P=0.026）直接相关。与 B6 状态不足相比，B6 状态充足的个体具有更高的高血浆 EPA（调整（a）OR：2.03，P=0.049）和 EPA/AA（aOR：3.83，P<0.0001）的可能性更大。总之，在美国老年人中，较高的 PLP 水平与 EPA、DHA、EPA+DHA、EPA/AA 和（EPA+DHA）/AA 的水平较高相关。B6 状态充足与高 EPA 和 EPA/AA 状态相关。这些发现表明，充足的维生素 B6 状态可能会对老年人的 PUFA 代谢产生积极影响。
