Department of Internal Medicine, Akasaka Sanno Medical Center, Tokyo 107-8402, Japan.
Clinical Research Center, International University of Health and Welfare, Tokyo 107-8402, Japan.
Nutrients. 2022 Jun 4;14(11):2349. doi: 10.3390/nu14112349.
Glucose is the most important source of energy and homeostasis. Recent investigations are clarifying that glucose metabolism might be altered in rheumatoid arthritis (RA), which would play a role in the inflammatory phenotype of rheumatoid synovial fibroblasts. It may also play a role in a variety of autoimmune diseases' pathophysiology by modulating immune responses and modifying autoantigen expressions. The research into glucose and its metabolism could lead to a better understanding of how carbohydrates contribute to the occurrence and duration of RA and other autoimmune diseases.
葡萄糖是最重要的能量来源和内环境稳定物质。最近的研究正在阐明葡萄糖代谢可能在类风湿关节炎（RA）中发生改变，这将在类风湿滑膜成纤维细胞的炎症表型中发挥作用。它还可以通过调节免疫反应和改变自身抗原表达在多种自身免疫性疾病的发病机制中发挥作用。对葡萄糖及其代谢的研究可以更好地了解碳水化合物如何导致 RA 和其他自身免疫性疾病的发生和持续。
