Key Laboratory of Separation Science for Analytical Chemistry , Dalian Institute of Chemical Physics, Chinese Academy of Sciences (CAS) , 457 Zhongshan Road , Dalian 116023 , China.
University of Chinese Academy of Sciences , 19 Yuquan Road , Beijing 100049 , China.
Anal Chem. 2019 Mar 19;91(6):3845-3851. doi: 10.1021/acs.analchem.8b04168. Epub 2019 Feb 27.
Illegal drug smugglings and crimes have long been a global concern, and an apparatus which can identify drugs on-the-spot is urgently demanded by law enforcement. A thermal desorption acetone-assisted photoionization miniature ion trap mass spectrometer was developed for on-site and rapid identification of illegal drugs at checkpoints. Acetone was chosen for dopant-assisted photoionization, and the sensitivity of selected drugs was further enhanced with protonated analyte molecular ions [M + H]. For example, the sensitivity of ephedrine was improved by as high as 22-fold. The mass discrimination effect, which was usually considered as a shortcoming of ion trap mass analyzer, was ingeniously utilized to eliminate the protonated acetone reagent ions and maximize the trapping efficiency of analyte ions in mass analyzer. Twenty-seven drugs were analyzed, and the limits of detection (LODs) of selected illegal drugs were at the nanogram level with analysis time of 2 s. Analyte/dopant ion peak intensity ratios in mass spectra could be used for quantitation to improve the quantitative analysis performance of miniature ion trap mass spectrometer equipped with a discontinuous atmospheric pressure interface (DAPI) with the prerequisite that dopant ions and analyte ions could be simultaneously and effectively trapped by the ion trap. The RSD of signal intensity was reduced from 25.3% to 8.5%, and the linear range was extended from 0.5-25 to 0.5-100 ng/μL for methamphetamine. A temperature-resolved thermal desorption sampling strategy was developed and used to distinguish illegal drug components in plant-based drug samples and drinks containing illegal drugs.
非法毒品走私和犯罪一直是全球关注的问题，执法部门迫切需要一种能够现场识别毒品的仪器。本文开发了一种热解吸丙酮辅助光电离微型离子阱质谱仪，用于在检查站现场和快速识别非法毒品。选择丙酮作为掺杂辅助光电离的试剂，并通过质子化分析物分子离子[M+H]进一步提高了所选药物的灵敏度。例如，麻黄碱的灵敏度提高了 22 倍。质量歧视效应通常被认为是离子阱质量分析仪的一个缺点，但本文巧妙地利用该效应来消除质子化丙酮试剂离子，并最大限度地提高质量分析仪中分析物离子的捕获效率。分析了 27 种药物，所选非法药物的检出限（LOD）达到纳克水平，分析时间为 2 秒。在配备不连续大气压接口（DAPI）的微型离子阱质谱仪中，通过同时有效捕获掺杂离子和分析物离子，可以使用质谱中分析物/掺杂离子峰强度比进行定量，从而改善定量分析性能。信号强度的 RSD 从 25.3%降低到 8.5%，并将线性范围从 0.5-25 扩展到 0.5-100ng/μL 用于甲基苯丙胺。开发了一种温度分辨热解吸采样策略，并用于区分植物源药物样品和含非法药物的饮料中的非法药物成分。
