Jatrolignans C 和 D：来自. 的新的新木脂素差向异构体。
Jatrolignans C and D: New Neolignan Epimers from .
机构信息
State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China.
Research Institute, School of Biological and Pharmaceutical Engineering, Lanzhou Jiaotong University, Lanzhou 730070, China.
出版信息
Molecules. 2022 May 31;27(11):3540. doi: 10.3390/molecules27113540.
Abstract
Two new neolignans jatrolignans, C () and D (), a pair of epimers, were isolated from the whole plants of L. (Euphorbiaceae). Their structures were determined with HRESIMS, IR, and NMR data analysis, and electronic circular dichroism (ECD) experiments via a comparison of the experimental and the calculated ECD spectra. Their antichlamydial activity was evaluated in They both showed dose-dependent antichlamydial effects. Significant growth inhibitory effects were observed at a minimum concentration of 40 μM.
摘要
从 L.（大戟科）全植物中分离得到两种新的 neolignans jatrolignans，C()和 D()，一对差向异构体。通过高分辨率质谱（HRESIMS）、红外（IR）和核磁共振（NMR）数据分析以及电子圆二色性（ECD）实验，通过比较实验和计算 ECD 光谱确定了它们的结构。评估了它们在 中的抗衣原体活性。它们都表现出剂量依赖性的抗衣原体作用。在最低浓度 40 μM 时观察到显著的生长抑制作用。
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