Neurogenetics Section, Centre for Addiction and Mental Health, Toronto, ON, Canada.
Int J Neuropsychopharmacol. 2012 Sep;15(8):1037-42. doi: 10.1017/S1461145711001313. Epub 2011 Aug 30.
Suicide is a prominent public health problem. Its aetiology is complex, and the brain-derived neurotrophic factor (BDNF) has been implicated. We performed the first meta-analysis of the functional BDNF marker Val⁶⁶Met (rs6265, 196G>A) in suicidal behaviour using data from 11 previously published samples plus our present sample (total n=3352 subjects, 1202 with history of suicidal behaviour. The meta-analysis including all 12 studies showed a trend for the Met-carrying genotypes and Met allele conferring risk for suicide (random-effects model p=0.096; ORMet-carrier=1.13, 95% CI 0.98-1.30, and random-effects model p=0.032; ORMet=1.16, 95% CI 1.01-1.32, respectively). Furthermore, we found the Met allele and the Met allele-carrying genotypes to be associated with history of suicide attempt (eight studies; allelic meta-analysis--random-effects model: p=0.013; fixed-effects model: p=0.006; genotypic meta-analysis--random-effects model: p=0.017; fixed-effects model: p=0.008). Taken together, the results from our study suggest that BDNF Val⁶⁶Met is involved in suicidality. Further studies are required to elucidate its role in suicidal behaviour.
自杀是一个突出的公共卫生问题。其病因复杂，脑源性神经营养因子（BDNF）与之相关。我们首次对自杀行为的功能性 BDNF 标志物 Val66Met（rs6265，196G>A）进行荟萃分析，使用了来自 11 项已发表样本的数据，加上我们的样本（总计 3352 名受试者，其中 1202 名有自杀行为史）。包括所有 12 项研究的荟萃分析显示，携带 Met 基因型和 Met 等位基因的个体自杀风险增加（随机效应模型 p=0.096；ORMet-carrier=1.13，95%CI 0.98-1.30，随机效应模型 p=0.032；ORMet=1.16，95%CI 1.01-1.32）。此外，我们发现 Met 等位基因和携带 Met 等位基因的基因型与自杀未遂史相关（8 项研究；等位基因荟萃分析-随机效应模型：p=0.013；固定效应模型：p=0.006；基因型荟萃分析-随机效应模型：p=0.017；固定效应模型：p=0.008）。综上所述，我们的研究结果表明 BDNF Val66Met 与自杀行为有关。需要进一步研究来阐明其在自杀行为中的作用。
