Shelley R K
University of Dublin, Trinity College, Ireland.
Br J Psychiatry. 1987 Dec;151:847-8. doi: 10.1192/bjp.151.6.847.
An elderly patient with bipolar manic-depressive psychosis, stabilised satisfactorily on lithium carbonate, developed acute symptoms of lithium toxicity shortly after commencing mefenamic acid. Vulnerability factors for the interaction may have included age, history of cardiac failure, and impaired glomerular function. It is hypothesised that the interaction may have been mediated by inhibition of prostaglandin activity.
一位患有双相躁郁症精神病的老年患者，在碳酸锂治疗下病情稳定，但在开始服用甲芬那酸后不久出现了锂中毒的急性症状。这种相互作用的易患因素可能包括年龄、心力衰竭病史和肾小球功能受损。据推测，这种相互作用可能是由前列腺素活性的抑制介导的。
