酪蛋白激酶II与受精卵母细胞中的减数分裂DNA相关。
The Casein Kinase II is associated with meiotic DNA in fertilized oocytes.
作者信息
Yim Nahyun, Medley Jeffrey C, Song Mi Hye
机构信息
Department of Biological Sciences, Oakland University, Rochester, MI, USA.
出版信息
MicroPubl Biol. 2022 Jun 6;2022. doi: 10.17912/micropub.biology.000583. eCollection 2022.
By using CRISPR/Cas9 genome-editing, we have generated epitope-tagged KIN-3 and KIN-10 expressing strains at the endogenous C-terminal loci in . We observed that both the catalytic (KIN-3::V5) and regulatory (KIN-10::2xMyc) subunits of the Casein Kinase II (CK2) holoenzyme complex are associated with meiotic DNA, enriched in the midvalent rings during meiotic divisions in fertilized oocytes.
通过使用CRISPR/Cas9基因组编辑技术，我们在[具体物种]的内源性C末端位点产生了表位标记的KIN-3和KIN-10表达菌株。我们观察到，酪蛋白激酶II（CK2）全酶复合物的催化亚基（KIN-3::V5）和调节亚基（KIN-10::2xMyc）均与减数分裂DNA相关联，在受精卵母细胞减数分裂过程中的中价环中富集。
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