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罕见症状揭示罕见脾淋巴瘤:以颈部和肩部疼痛为首发表现的原发性皮肤弥漫大B细胞淋巴瘤病例报告

Unusual symptoms reveal a rare splenic lymphoma: a case report of PS-DLBCL with neck and shoulder pain as the initial presentation.

作者信息

Hu Shifu, Hao Yuanyuan, Liu Xiangyu, Liu Hanbo

机构信息

Department of General Surgery, Tianjin Xiqing Hospital, Tianjin, China.

Department of Geriatrics, Tianjin Xiqing Hospital, Tianjin, China.

出版信息

Front Oncol. 2025 Feb 4;15:1449966. doi: 10.3389/fonc.2025.1449966. eCollection 2025.

Abstract

The rare occurrence of diffuse large B-cell lymphoma (DLBCL) limited to the spleen presents difficulties in diagnosis. A case report details a patient whose initial symptoms were neck and shoulder pain, subsequently diagnosed as spontaneous spleen rupture, a rare complication of primary splenic lymphoma. Following a splenectomy, the patient was confirmed to have primary splenic DLBCL and made a good postoperative recovery. This report highlights the diagnostic dilemmas in atypical presentations, where neck and shoulder pain may be the only early sign of a neglected spleen rupture, lacking typical symptoms of the underlying disease. In cases of patients who are not stable, the recommended first imaging method is a focused assessment using sonography for trauma (FAST), as CT scans have a high level of sensitivity. Treatment is determined by hemodynamic status, with conservative management for stable patients and surgical intervention for unstable patients. The importance of recognizing spontaneous spleen rupture as a critical yet uncommon possibility in acute abdominal cases, especially in instances of primary splenic DLBCL, is emphasized in the report.

摘要

罕见的局限于脾脏的弥漫性大B细胞淋巴瘤(DLBCL)在诊断上存在困难。一份病例报告详细描述了一名患者,其最初症状为颈部和肩部疼痛,随后被诊断为自发性脾破裂,这是原发性脾淋巴瘤的一种罕见并发症。脾切除术后,该患者被确诊为原发性脾DLBCL,术后恢复良好。本报告强调了非典型表现中的诊断困境,即颈部和肩部疼痛可能是被忽视的脾破裂的唯一早期迹象,而缺乏潜在疾病的典型症状。对于病情不稳定的患者,推荐的首选影像学检查方法是使用创伤超声重点评估(FAST),因为CT扫描具有较高的敏感性。治疗取决于血流动力学状态,稳定患者采用保守治疗,不稳定患者则进行手术干预。该报告强调了认识到自发性脾破裂在急性腹部病例中是一种关键但不常见的可能性的重要性,尤其是在原发性脾DLBCL的情况下。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb83/11832353/940a339d4d36/fonc-15-1449966-g001.jpg

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