Kankilic Nazım, Aslan Aydın, Karahan Oguz, Demirtas Sinan, Caliskan Ahmet, Yavuz Celal
1 Department of Cardiovascular Surgery, Kırklareli State Hospital, Kırklareli, Turkey.
2 Department of Radiology, Diyarbakir Gazi Yasargil Education and Research Hospital, Diyarbakir, Turkey.
Vascular. 2018 Aug;26(4):356-361. doi: 10.1177/1708538117742827. Epub 2017 Nov 28.
Objectives Behcet's disease is a multisystemic, inflammatory disease. Various factors have been implicated in the disease, including genetics, infections, immunoglobulins, immune complexes, antibodies, and oxidative stress. However, the underlying etiopathogenesis remains unclear. Behcet's disease can occur with or without vascular involvement. This prospective study investigated the relationship between the intima-media thickness of the major arteries, in addition to other factors affecting the disease process, in Behcet's disease without vascular involvement. Methods Twenty-four patients (average age: 38.50 ± 10.931) without vascular involvement or any vascular complaints who were diagnosed with Behcet's disease were included in the study. Sixteen healthy subjects (average age: 39.75 ± 7.793) were included as a control group. Demographic information and medical histories were recorded, and routine blood tests were performed in both groups. The intima-media thickness of the subclavian, axillary, femoral, and carotid arteries of all the participants were recorded using Doppler ultrasonography. The data were then subjected to intergroup statistical and correlation analyses. Results There were no significant differences between the arterial intima-media thickness values of the Behcet's disease patients and those of the control group ( p > 0.05). However, there was a significant difference between the neutrophil-lymphocyte ratio ( p = 0.004), low-density lipoprotein ( p = 0.007), and triglyceride ( p = 0042) levels of the two groups. Significant correlations were found between intima-media thickness and neutrophil-lymphocyte ratio levels ( p = 0.012) and the disease duration ( p = 0.030). There was also a significant correlation between the intima-media thickness of the femoral artery and disease duration ( p = 0.014). Conclusions The results showed that the duration of illness had a significant effect on arterial intima-media thickness in Behcet's disease. Blood neutrophil-lymphocyte ratio levels were also associated with increased intima-media thickness.
目的 白塞病是一种多系统炎症性疾病。多种因素与该疾病有关，包括遗传、感染、免疫球蛋白、免疫复合物、抗体和氧化应激。然而，其潜在的病因发病机制仍不清楚。白塞病可伴有或不伴有血管受累。本前瞻性研究调查了无血管受累的白塞病患者主要动脉内膜中层厚度与影响疾病进程的其他因素之间的关系。方法 本研究纳入了24例诊断为白塞病且无血管受累或任何血管相关主诉的患者（平均年龄：38.50 ± 10.931）。纳入16名健康受试者（平均年龄：39.75 ± 7.793）作为对照组。记录两组的人口统计学信息和病史，并进行常规血液检查。使用多普勒超声记录所有参与者的锁骨下动脉、腋动脉、股动脉和颈动脉的内膜中层厚度。然后对数据进行组间统计和相关性分析。结果 白塞病患者与对照组的动脉内膜中层厚度值无显著差异（p > 0.05）。然而，两组的中性粒细胞与淋巴细胞比值（p = 0.004）、低密度脂蛋白（p = 0.007）和甘油三酯（p = 0.042）水平存在显著差异。内膜中层厚度与中性粒细胞与淋巴细胞比值水平（p = 0.012）和病程（p = 0.030）之间存在显著相关性。股动脉内膜中层厚度与病程之间也存在显著相关性（p = 0.014）。结论 结果表明，病程对白塞病患者的动脉内膜中层厚度有显著影响。血液中性粒细胞与淋巴细胞比值水平也与内膜中层厚度增加有关。
