Xu Bin, Ma Jian-Xiong, Ma Xin-Long, Jia Hao-Bo, Feng Rui, Xu Li-Yan
Biomechanics Laboratory of Orthopaedic Institute of Tianjin Hospital , Tianjin , China ; Tianjin Medical University , Tianjin , China.
Biomechanics Laboratory of Orthopaedic Institute of Tianjin Hospital , Tianjin , China.
PeerJ. 2015 Apr 23;3:e910. doi: 10.7717/peerj.910. eCollection 2015.
To comprehensively evaluate the association between rs7517847 and rs2201841 polymorphisms in the Interleukin-23 (IL-23) receptor gene and ankylosing spondylitis (AS), a meta-analysis was performed. The Pubmed, Embase, MEDLINE, Cochrane, China National Knowledge Infrastructure (CNKI), VIP, Wanfang and China Biology Medicine disc (CBMdisc) databases were searched to identify eligible studies on rs7517847 and rs2201841 polymorphisms in the IL-23 receptor gene and AS that were published through September 2014. Data of interest were extracted from each study, and the meta-analysis was performed using STATA 12.0. Four studies were eligible for the meta-analysis and included a total patient population of 2,465. With regards to rs7517847, the current study showed that the genotype GG and allele G might play a protective role during AS (OR = 0.76, 95% CI [0.59-0.99]; OR = 0.88, 95% CI [0.78-0.99] for homozygote and allelic models, respectively). However, according to the meta-analysis, there was no statistical association between the genotype or allele of rs2201841 and an individual's susceptibility to AS in all genetic models. In conclusion, it was the IL-23 rs7517847 polymorphism rather than the rs2201841 polymorphism that had a statistical association with AS. Nevertheless, more evidence is needed to confirm this result. Consequently, it is necessary to carry out more high-quality studies to confirm the associations between these two single nucleotide polymorphisms and AS.
为全面评估白细胞介素-23（IL-23）受体基因中rs7517847和rs2201841多态性与强直性脊柱炎（AS）之间的关联，我们进行了一项荟萃分析。检索了PubMed、Embase、MEDLINE、Cochrane、中国知网（CNKI）、维普（VIP）、万方和中国生物医学文献数据库（CBMdisc），以确定截至2014年9月发表的关于IL-23受体基因中rs7517847和rs2201841多态性与AS的符合条件的研究。从每项研究中提取感兴趣的数据，并使用STATA 12.0进行荟萃分析。四项研究符合荟萃分析的条件，共纳入2465例患者。关于rs7517847，本研究表明基因型GG和等位基因G在AS发病过程中可能起保护作用（纯合子模型和等位基因模型的OR分别为0.76，95%CI[0.59 - 0.99]；OR为0.88，95%CI[0.78 - 0.99]）。然而，根据荟萃分析，在所有遗传模型中，rs2201841的基因型或等位基因与个体对AS的易感性之间无统计学关联。总之，与AS存在统计学关联的是IL-23 rs7517847多态性而非rs2201841多态性。然而，需要更多证据来证实这一结果。因此，有必要开展更多高质量研究来证实这两个单核苷酸多态性与AS之间的关联。
