Dermatologist, Private Practice, Ankara, Turkey.
Department of Dermatology, Gülhane Training and Research Hospital, University of Health Sciences, Ankara, Turkey.
J Cosmet Dermatol. 2022 Aug;21(8):3219-3225. doi: 10.1111/jocd.15152. Epub 2022 Jun 26.
Exosomes, as a family member of extracellular vesicles, are cell-secreted nanoscale structures that play pivotal roles in regulating physiological and pathophysiological processes of the skin. Exosomes induce communication between cells and are responsible for transporting cellular components such as microRNAs, mRNAs, DNA, lipids, metabolites, and cell-surface proteins. Numerous preclinical and clinical trials searched the contribution of exosomes to skin functions and disorders. Thus, exosomes are gaining increasing attention within investigational dermatology. In advance, stem-cell-derived exosomes were integrated into the functional cosmetics industry nominated as cell-free regenerative medicine.
This review aims to demonstrate the roles of exosomes in inflammatory skin disorders, stem cell, and tumor biology through a comprehensive evaluation of the diagnostic, prognostic, and therapeutic perspectives.
A comprehensive literature search was performed using electronic online databases "PubMed" and "Google Scholar" using key words ''exosomes'', ''skin'', ''wound healing''.
Exosomes are regarded as promising diagnostic and prognostic biomarkers for various skin diseases. Future prospects are repurposing exosomes to treat skin disorders, either as drug carriers or drugs themselves.
外泌体作为细胞外囊泡的一个家族成员，是细胞分泌的纳米级结构，在调节皮肤的生理和病理生理过程中起着关键作用。外泌体诱导细胞间的通讯，并负责运输细胞成分，如 microRNAs、mRNAs、DNA、脂质、代谢物和细胞表面蛋白。许多临床前和临床试验都在研究外泌体对皮肤功能和疾病的贡献。因此，外泌体在研究性皮肤病学中受到越来越多的关注。此外，干细胞衍生的外泌体被整合到功能性化妆品行业中，被称为无细胞再生医学。
本综述旨在通过全面评估诊断、预后和治疗的角度，展示外泌体在炎症性皮肤疾病、干细胞和肿瘤生物学中的作用。
使用电子在线数据库“PubMed”和“Google Scholar”，使用关键字“外泌体”、“皮肤”、“伤口愈合”进行全面的文献检索。
外泌体被认为是各种皮肤疾病有前途的诊断和预后生物标志物。未来的前景是将外泌体重新用于治疗皮肤疾病，无论是作为药物载体还是药物本身。
