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HIV感染与进展中的细胞外囊泡：机制及诊疗意义

The extracellular vesicles in HIV infection and progression: mechanisms, and theranostic implications.

作者信息

Tang Zhen, Lu Yao, Dong Jiu-Long, Wu Wen, Li Jian

机构信息

AIDS Prevention and Control Center of Yichang Third People's Hospital, Third People's Hospital Affiliated to Sanxia University, Yichang, Hubei, China.

Yichang Changyang County People's Hospital, Yichang, Hubei, China.

出版信息

Front Bioeng Biotechnol. 2024 Apr 9;12:1376455. doi: 10.3389/fbioe.2024.1376455. eCollection 2024.

DOI:10.3389/fbioe.2024.1376455
PMID:38655385
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11035885/
Abstract

Extracellular vesicles (EVs), these minute yet mighty cellular messengers are redefining our understanding of a spectrum of diseases, from cancer to cardiovascular ailments, neurodegenerative disorders, and even infectious diseases like HIV. Central to cellular communication, EVs emerge as both potent facilitators and insightful biomarkers in immune response and the trajectory of disease progression. This review ventures deep into the realm of EVs in HIV-unraveling their pivotal roles in diagnosis, disease mechanism unravelling, and therapeutic innovation. With a focus on HIV, we will highlights the transformative potential of EVs in both diagnosing and treating this formidable virus. Unveiling the intricate dance between EVs and HIV, the review aims to shed light on novel therapeutic strategies that could significantly benefit HIV therapy, potentially even leading to the eradication of HIV.

摘要

细胞外囊泡（EVs），这些微小却强大的细胞信使正在重新定义我们对一系列疾病的理解，从癌症到心血管疾病、神经退行性疾病，甚至像艾滋病这样的传染病。作为细胞通讯的核心，细胞外囊泡在免疫反应和疾病进展轨迹中既是强大的促进者，又是有洞察力的生物标志物。本综述深入探讨了细胞外囊泡在艾滋病领域的情况——揭示它们在诊断、疾病机制解析和治疗创新中的关键作用。以艾滋病为重点，我们将强调细胞外囊泡在诊断和治疗这种可怕病毒方面的变革潜力。通过揭示细胞外囊泡与艾滋病病毒之间错综复杂的相互作用，本综述旨在阐明可能显著有益于艾滋病治疗的新治疗策略，甚至有可能导致艾滋病的根除。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24ef/11035885/eff43fe62bdc/fbioe-12-1376455-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24ef/11035885/68c1b64ea254/fbioe-12-1376455-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24ef/11035885/f1de9e68bd27/fbioe-12-1376455-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24ef/11035885/c136834f101f/fbioe-12-1376455-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24ef/11035885/0d819cd259b7/fbioe-12-1376455-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24ef/11035885/eff43fe62bdc/fbioe-12-1376455-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24ef/11035885/68c1b64ea254/fbioe-12-1376455-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24ef/11035885/f1de9e68bd27/fbioe-12-1376455-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24ef/11035885/c136834f101f/fbioe-12-1376455-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24ef/11035885/0d819cd259b7/fbioe-12-1376455-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24ef/11035885/eff43fe62bdc/fbioe-12-1376455-g005.jpg

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Advanced extracellular vesicle bioinformatic nanomaterials: from enrichment, decoding to clinical diagnostics.先进的细胞外囊泡生物信息纳米材料：从富集、解码到临床诊断。
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CRISPR/Cas9: a tool to eradicate HIV-1.
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