Tunc Seyhmus, Oglak Suleyman Cemil, Olmez Fatma, Ozkose Zeynep Gedik
Department of Obstetrics and Gynecology, Health Sciences University, Gazi Yasargil Training and Research Hospital, Diyarbakir, Turkey.
Department of Obstetrics and Gynecology, Health Sciences University, Kanuni Sultan Suleyman Training and Research Hospital, Istanbul, Turkey.
J Coll Physicians Surg Pak. 2022 Jun;32(6):722-727. doi: 10.29271/jcpsp.2022.06.722.
To examine the performance of first-trimester visceral (pre-peritoneal), subcutaneous, and total adipose tissue thickness (ATT) to predict the patients with subsequently developing gestational Diabetes mellitus (GDM).
Observational study.
Department of Obstetrics and Gynecology, Diyarbakır Gazi Yaşargil Training and Research Hospital from January 2021 to July 2021.
A total of 100 pregnant women underwent sonographic measurement of subcutaneous and visceral ATT at 11-14 weeks' gestation. A 75-g oral glucose tolerance test (OGTT) was conducted between 24-28 weeks of pregnancy for the diagnosis of GDM.
The mean visceral, subcutaneous, and total ATT were significantly higher in the GDM group (24.75 ± 10.34 mm, 26.33 ± 5.33 mm, 51.08 ± 14.4 mm) than in the group without a GDM diagnosis (16.68 ± 6.73 mm, 17.68 ± 4.86 mm, 34.25 ± 11.04, respectively, p<0.001). A pre-gestational BMI >30 kg/m2 (Odds ratio [OR]=10.20, 95% CI=2.519-41.302, p=0.001), visceral ATT (OR=33.2, 95% CI=7.395-149.046, p<0.001), subcutaneous ATT (OR=4.543, 95% CI=1.149-17.960, p=0.031), and total ATT (OR=10.895, 95% CI=2.682-44.262, p=0.001) were the factors that were found to be significantly associated with the subsequent development of GDM after adjusting for potential confounders (maternal age, and parity). The most significant risk factor for the prediction of GDM is visceral ATT with an OR of 33.2.
US measurement of maternal visceral ATT during first-trimester fetal aneuploidy screening is a reliable, reproducible, cost-effective, and safe method to identify pregnant women at high risk for GDM.
Gestational diabetes mellitus, Visceral adipose tissue thickness, Subcutaneous adipose tissue thickness.
研究孕早期内脏（腹膜前）、皮下及总脂肪组织厚度（ATT）预测随后发生妊娠期糖尿病（GDM）患者的效能。
观察性研究。
2021年1月至2021年7月在迪亚巴克尔加齐·亚萨尔吉尔培训与研究医院妇产科。
共100名孕妇在妊娠11 - 14周时接受皮下及内脏ATT的超声测量。在妊娠24 - 28周进行75克口服葡萄糖耐量试验（OGTT）以诊断GDM。
GDM组的平均内脏、皮下及总ATT（分别为24.75±10.34毫米、26.33±5.33毫米、51.08±14.4毫米）显著高于未诊断为GDM的组（分别为16.68±6.73毫米、17.68±4.86毫米、34.25±11.04毫米，p<0.001）。调整潜在混杂因素（母亲年龄和产次）后，孕前体重指数>30 kg/m²（优势比[OR]=10.20，95%可信区间[CI]=2.519 - 41.302，p=0.001）、内脏ATT（OR=33.2，95% CI=7.395 - 149.046，p<0.001）、皮下ATT（OR=4.543，95% CI=1.149 - 17.960，p=0.031）和总ATT（OR=10.895，95% CI=2.682 - 44.262，p=0.001）是与随后发生GDM显著相关的因素。预测GDM的最显著危险因素是内脏ATT，OR为33.2。
孕早期胎儿非整倍体筛查期间超声测量母亲内脏ATT是识别GDM高危孕妇的可靠、可重复、经济有效且安全的方法。
妊娠期糖尿病；内脏脂肪组织厚度；皮下脂肪组织厚度
