D'Ambrosi Francesco, Crovetto Francesca, Colosi Enrico, Fabietti Isabella, Carbone Floriana, Tassis Beatrice, Motta Silvia, Bulfoni Alessandro, Fedele Luigi, Rossi Gabriele, Persico Nicola
Department of Obstetrics and Gynecology "L. Mangiagalli," Fondazione IRCCS "Ca' Granda" - Ospedale Maggiore Policlinico, Milan, Italy.
Fetal Diagn Ther. 2018;43(2):143-147. doi: 10.1159/000475988. Epub 2017 Jun 17.
To compare the sonographic measurement of maternal subcutaneous and visceral adipose thickness between pregnant women with gestational diabetes mellitus (GDM) and patients with nondiabetic pregnancies.
Adipose thickness was measured by transabdominal ultrasound in pregnant women attending our antenatal clinics at 24-28 weeks' gestation. All patients underwent a 75-g oral glucose challenge as a diagnostic test for GDM.
The study population comprised 56 women with a positive glucose challenge test and 112 nondiabetic pregnancies. Measurements of subcutaneous and visceral adipose tissues were converted into multiples of the median (MoM), adjusted for gestational age. The mean subcutaneous thickness MoM in patients with GDM was significantly higher compared to nondiabetic pregnancies (1.31 vs. 1.07; p = 0.011). Similarly, the mean visceral thickness MoM was higher in women with a positive oral glucose tolerance test compared to controls (1.61 vs. 1.06; p < 0.001). Multivariate logistic regression analysis demonstrated that visceral adipose thickness, but not subcutaneous thickness, was significantly and independently associated with GDM (odds ratio 34.047, 95% confidence interval 9.489-122.166).
Sonographic thickness of maternal visceral adipose tissue at 24-28 weeks' gestation was higher in women with GDM compared to nondiabetic pregnancies, independently from other known risk factors associated with GDM.
比较妊娠期糖尿病（GDM）孕妇与非糖尿病孕妇孕期母体皮下及内脏脂肪厚度的超声测量结果。
对在我院产前门诊就诊、妊娠24 - 28周的孕妇进行经腹超声测量脂肪厚度。所有患者均接受75克口服葡萄糖耐量试验作为GDM的诊断测试。
研究人群包括56例葡萄糖耐量试验阳性的女性和112例非糖尿病孕妇。将皮下和内脏脂肪组织的测量值转换为中位数倍数（MoM），并根据孕周进行调整。GDM患者的平均皮下厚度MoM显著高于非糖尿病孕妇（1.31对1.07；p = 0.011）。同样，口服葡萄糖耐量试验阳性女性的平均内脏厚度MoM高于对照组（1.61对1.06；p < 0.001）。多因素逻辑回归分析表明，内脏脂肪厚度而非皮下脂肪厚度与GDM显著且独立相关（比值比34.047，95%置信区间9.489 - 122.166）。
与非糖尿病孕妇相比，GDM孕妇在妊娠24 - 28周时母体内脏脂肪组织的超声厚度更高，且独立于其他已知的与GDM相关的危险因素。
