Topal Ugur, Guler Serkan, Teke Zafer, Karakose Erdal, Kurtulus Idris, Bektas Hasan
Department of Surgical Oncology, University of Health Sciences, Basaksehir Cam and Sakura City Hospital, Istanbul, Turkey.
Department of General Surgery, University of Health Sciences, Basaksehir Cam and Sakura City Hospital, Istanbul, Turkey.
J Coll Physicians Surg Pak. 2022 Jun;32(6):751-757. doi: 10.29271/jcpsp.2022.06.751.
To investigate the value of preoperative haemoglobin, albumin, lymphocyte, and platelet (HALP) score in predicting tumour budding in colorectal carcinoma.
Observational study.
University of Health Sciences, Başakşehir Çam and Sakura City Hospital İstanbul/Turkey, between May 2020 and May 2021.
The colorectal cancer patients who underwent surgery were divided into two groups according to the presence or absence of tumour budding. A total of 110 patients were included in the study, and there were 31 patients in group 1 and 79 patients in group 2. The predictive value of the HALP score in predicting tumour budding at the determined cut-off point was evaluated.
The mean HALP score was similar in both groups (p=0.459). The rate of lymphovascular invasion was higher in group 2 (p=0.002), and T3 and T4 tumours were more common in group 2 (p<0.001). The number of metastatic lymph nodes was higher in group 2 (p=0.049). When the patients in group 2 were divided into subgroups according to the degree of tumour budding, the HALP score differed between intermediate and high budding groups (p=0.032). A HALP value of >31.6 predicted the presence of tumour budding with a sensitivity of 70.89% and a specificity of 48.39%.
The presence of tumour budding is associated with aggressive phenotypic features in colorectal carcinoma. The preoperative prediction of tumour budding can serve as a guide in the development of individualised therapy plans. The HALP score was associated with the presence of intermediate or high degree of tumour budding.
Colorectal cancer, Tumor, Pathology, Hemoglobin, Albumin.
探讨术前血红蛋白、白蛋白、淋巴细胞和血小板（HALP）评分在预测结直肠癌肿瘤芽生中的价值。
观察性研究。
土耳其伊斯坦布尔健康科学大学巴沙克谢希尔·卡姆和樱花市医院，2020年5月至2021年5月。
将接受手术的结直肠癌患者根据有无肿瘤芽生分为两组。本研究共纳入110例患者，其中第1组31例，第2组79例。评估HALP评分在确定的临界值时预测肿瘤芽生的价值。
两组的平均HALP评分相似（p = 0.459）。第2组的脉管侵犯率更高（p = 0.002），且第2组中T3和T4期肿瘤更常见（p < 0.001）。第2组的转移淋巴结数量更多（p = 0.049）。当根据肿瘤芽生程度将第2组患者分为亚组时，中度和高度芽生组之间的HALP评分存在差异（p = 0.032）。HALP值>31.6预测肿瘤芽生的存在，敏感性为70.89%，特异性为48.39%。
肿瘤芽生的存在与结直肠癌侵袭性表型特征相关。术前预测肿瘤芽生可为制定个体化治疗方案提供指导。HALP评分与中度或高度肿瘤芽生的存在相关。
结直肠癌；肿瘤；病理学；血红蛋白；白蛋白
