Blanken R, Nater J P, Veenhoff E
Contact Dermatitis. 1987 Feb;16(2):79-83. doi: 10.1111/j.1600-0536.1987.tb01383.x.
This study evaluates the protective capacity of 4 barrier creams and 2 methacrylate spray coatings against skin contact with epoxy resins. The effect of these materials on the strength and on the surface area of patch test reactions caused by epoxy resin was assessed in 11 volunteers with a known allergy to epoxy resins. Standard amounts of barrier cream and spray coating were applied on the skin. Then patch tests were carried out with epoxy resin on the pretreated sites. After 24 h patches were removed, 48 h thereafter the strength and surface area of the reactions were scored. Results were compared with the score of a control test. The use of 2 barrier creams resulted in a significant reduction of the surface area of the patch test reactions. Spray coatings significantly reduced both the strength and the surface area of the reactions. Our results suggest that methacrylate spray coatings and barrier creams may provide protection against epoxy resins during a test period of 24 h. However, the development of new formulations, adapted more specifically to this purpose, is necessary.
本研究评估了4种防护霜和2种甲基丙烯酸酯喷雾涂层对皮肤接触环氧树脂的防护能力。在11名已知对环氧树脂过敏的志愿者中，评估了这些材料对环氧树脂引起的斑贴试验反应强度和表面积的影响。将标准量的防护霜和喷雾涂层涂抹于皮肤上。然后在预处理部位用环氧树脂进行斑贴试验。24小时后移除贴片，再过48小时对反应的强度和表面积进行评分。将结果与对照试验的评分进行比较。使用2种防护霜可显著减少斑贴试验反应的表面积。喷雾涂层可显著降低反应的强度和表面积。我们的结果表明，甲基丙烯酸酯喷雾涂层和防护霜在24小时的试验期内可能提供对环氧树脂的防护。然而，有必要开发更专门适用于此目的的新配方。
