缺氧诱导因子：在心血管疾病进展、预防和治疗中的作用。
Hypoxia-inducible factors: roles in cardiovascular disease progression, prevention, and treatment.
机构信息
Armstrong Oxygen Biology Research Center, Vascular Program, Institute for Cell Engineering; and Departments of Genetic Medicine, Pediatrics, Medicine, Oncology, Radiation Oncology, and Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
出版信息
Cardiovasc Res. 2023 Mar 31;119(2):371-380. doi: 10.1093/cvr/cvac089.
Hypoxia-inducible factors (HIF)-1 and HIF-2 are master regulators of oxygen homeostasis that regulate the expression of thousands of genes in order to match O2 supply and demand. A large body of experimental data links HIF activity to protection against multiple disorders affecting the cardiovascular system: ischemic cardiovascular disease (including coronary artery disease and peripheral artery disease), through collateral blood vessel formation and preconditioning phenomena; emphysema; lymphedema; and lung transplant rejection. In these disorders, strategies to increase the expression of one or both HIFs may be of therapeutic utility. Conversely, extensive data link HIFs to the pathogenesis of pulmonary arterial hypertension and drugs that inhibit one or both HIFs may be useful in treating this disease.
缺氧诱导因子 (HIF)-1 和 HIF-2 是氧平衡的主要调节因子，它们调节数千个基因的表达，以匹配 O2 的供应和需求。大量的实验数据将 HIF 活性与多种影响心血管系统的疾病的保护联系起来：缺血性心血管疾病（包括冠心病和外周动脉疾病），通过侧支血管形成和预处理现象；肺气肿；淋巴水肿；和肺移植排斥。在这些疾病中，增加一种或两种 HIF 表达的策略可能具有治疗作用。相反，大量数据将 HIFs 与肺动脉高压的发病机制联系起来，抑制一种或两种 HIFs 的药物可能对治疗这种疾病有用。
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