Neurophotonics and Mechanical Systems Biology, ICFO - Institut de Ciències Fotòniques, The Barcelona Institute of Science and Technology, Castelldefels (Barcelona) 08860, Spain.
Neurophotonics and Mechanical Systems Biology, ICFO - Institut de Ciències Fotòniques, The Barcelona Institute of Science and Technology, Castelldefels (Barcelona) 08860, Spain.
Curr Opin Neurobiol. 2022 Aug;75:102574. doi: 10.1016/j.conb.2022.102574. Epub 2022 Jun 7.
Proprioception and visceral mechanosensation provide important information about the location and deformation of the body parts in space and time. These deformations arise from muscle contraction during locomotion, but also from volume changes in organs that are subjected to stresses as a part of their physiological function. These internal morphodynamics give rise to periodic contraction-relaxation cycles with surprisingly constant amplitudes and the maintenance of these optimal driving patterns is remarkably robust against external and internal perturbations. One of the underlying reason for this robustness is an internal feedback mechanism in which specialized sensory cells and neurons signal the mechanical deformation of the inner workings of our organs, from the body to the brain, which subsequently adjust the driver to a predetermined physiological setpoint. Here, we review recent progress in the field of visceral mechanosensation and proprioception in Caenorhabditis elegans and discuss how future studies with this model can be used to gain insight into mechanosensory body-brain interactions in mammals.
本体感觉和内脏机械感觉提供了关于身体部位在空间和时间中的位置和变形的重要信息。这些变形来自于运动过程中的肌肉收缩，但也来自于器官的体积变化，这些器官在其生理功能中受到压力的影响。这些内部形态动力学产生了周期性的收缩-松弛循环，其幅度惊人地恒定，并且这些最佳驱动模式的维持对外部和内部干扰具有显著的鲁棒性。这种鲁棒性的一个潜在原因是内部反馈机制，其中专门的感觉细胞和神经元信号传递我们器官内部运作的机械变形，从身体到大脑，随后将驱动器调整到预定的生理设定点。在这里，我们回顾了秀丽隐杆线虫内脏机械感觉和本体感觉领域的最新进展，并讨论了如何利用该模型的未来研究来深入了解哺乳动物的机械感觉身体-大脑相互作用。
