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是否应考虑为择期全膝关节置换术患者设定年龄界限?基于患者报告的结果分析手术成功率。

Should an Age Cutoff Be Considered for Elective Total Knee Arthroplasty Patients? An Analysis of Operative Success Based on Patient-Reported Outcomes.

机构信息

Department of Orthopaedic Surgery, Orthopedic and Rheumatologic Institute, Cleveland Clinic, Cleveland, Ohio.

Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio.

出版信息

J Knee Surg. 2023 Jul;36(9):1001-1011. doi: 10.1055/s-0042-1748821. Epub 2022 Jun 10.

Abstract

Total knee arthroplasty (TKA) is increasing in the elderly population; however, some patients, family members, and surgeons raise age-related concerns over expected improvement and risks. This study aimed to (1) evaluate the relationship between age and change in patient-reported outcome measures (PROMs); (2) model how many patients would be denied improvements in PROMs if hypothetical age cutoffs were implemented; and (3) assess length of stay (LOS), readmission, reoperation, and mortality per age group. A prospective cohort of 4,396 primary TKAs (August 2015-August 2018) was analyzed. One-year PROMs were evaluated via Knee injury and Osteoarthritis Outcome Score (KOOS)-pain, -physical function short form (-PS), and -quality of life (-QOL), as well as Veterans Rand-12 (VR-12) physical (-PCS) and mental component (-MCS) scores. Positive predictive values (PPVs) of the number of postoperative "failures" (i.e., unattained minimal clinically important difference in PROMs) relative to number of hypothetically denied "successes" from a theoretical age-group restriction was estimated. KOOS-PS and QOL median score improvements were equivalent among all age groups ( = 0.946 and  = 0.467, respectively). KOOS-pain improvement was equivalent for ≥80 and 60-69-year groups (44.4 [27.8-55.6]). Median VR-12 PCS improvements diminished as age increased (15.9, 14.8, and 13.4 for the 60-69, 70-79, and ≥80 groups, respectively;  = 0.002) while improvement in VR-12 MCS was similar among age groups ( = 0.440). PPV for failure was highest in the ≥80 group, yet remained <34% for all KOOS measures. Overall mortality was highest in the ≥80 group (2.14%,  = 9). LOS >2, non-home discharge, and 90-day readmission were highest in the ≥80 group (8.11% [ = 24], < 0.001; 33.7% [ = 109],  < 0.001; and 34.4% [ = 111],  = 0.001, respectively). Elderly patients exhibited similar improvement in PROMs to younger counterparts despite higher LOS, non-home discharge, and 90-day readmission. Therefore, special care pathways should be implemented for those age groups.

摘要

全膝关节置换术(TKA)在老年人群中越来越常见;然而,一些患者、家属和外科医生对与年龄相关的预期改善和风险表示担忧。本研究旨在:(1)评估年龄与患者报告的结果测量(PROM)变化之间的关系;(2)如果实施假设的年龄截止值,模拟有多少患者会被拒绝改善 PROM;(3)评估每个年龄组的住院时间(LOS)、再入院、再次手术和死亡率。对 4396 例原发性 TKA(2015 年 8 月至 2018 年 8 月)进行前瞻性队列研究。通过膝关节损伤和骨关节炎结果评分(KOOS)-疼痛、-物理功能简短形式(-PS)和-生活质量(-QOL),以及退伍军人 Rand-12(VR-12)的身体(-PCS)和精神成分(-MCS)评分评估 1 年的 PROM。估计相对于从理论上的年龄组限制中拒绝的“成功”数量,术后“失败”(即 PROM 未达到最小临床重要差异)的数量的阳性预测值(PPV)。所有年龄组的 KOOS-PS 和 QOL 中位数评分改善均相当( = 0.946 和  = 0.467)。≥80 岁和 60-69 岁组的 KOOS-疼痛改善相当(分别为 44.4 [27.8-55.6])。随着年龄的增长,VR-12 PCS 改善的中位数逐渐减少(60-69、70-79 和≥80 组分别为 15.9、14.8 和 13.4; = 0.002),而 VR-12 MCS 的改善在各年龄组相似( = 0.440)。失败的 PPV 在≥80 岁组最高,但所有 KOOS 指标的比例仍<34%。≥80 岁组的总体死亡率最高(2.14%, = 9)。LOS>2、非家庭出院和 90 天再入院在≥80 岁组中最高(8.11% [ = 24],< 0.001;33.7% [ = 109],< 0.001;和 34.4% [ = 111], = 0.001)。尽管 LOS、非家庭出院和 90 天再入院较高,但老年患者的 PROM 改善与年轻患者相似。因此,应针对这些年龄组实施特殊的护理途径。

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