Department of Neuroscience and Cell Biology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Addiction Research Unit, Osaka Psychiatric Research Center, Osaka Psychiatric Medical Center, Osaka, 541-8567, Japan.
Sci Rep. 2022 Jun 10;12(1):9634. doi: 10.1038/s41598-022-13655-7.
Ulcerative colitis (UC) is a non-specific inflammatory bowel disease that causes ulcers and erosions in the colonic mucosa and becomes chronic with cycles of amelioration and exacerbation. Because its exact etiology remains largely unclear, and the primary therapy is limited to symptomatic treatment, the development of new therapeutic agent for UC is highly desired. Because one of the disease pathogenesis is involvement of oxidative stress, it is likely that an appropriate antioxidant will be an effective therapeutic agent for UC. Our silicon (Si)-based agent, when ingested, allowed for stable and persistent generation of massive amounts of hydrogen in the gastrointestinal tract. We demonstrated the Si-based agent alleviated the mental symptom as well as the gastrointestinal symptoms, inflammation, and oxidation associated with dextran sodium sulfate-induced UC model through Hydrogen and antioxidant sulfur compounds. As the Si-based agent was effective in treating UC in the brain and large intestine of mice, it was considered to be capable of suppressing exacerbations and sustaining remission of UC.
溃疡性结肠炎（UC）是一种非特异性炎症性肠病，导致结肠黏膜出现溃疡和糜烂，并呈现出缓解和加重的慢性周期性特征。由于其确切病因在很大程度上仍不清楚，且主要治疗方法仅限于对症治疗，因此非常需要开发用于 UC 的新型治疗药物。由于疾病发病机制之一涉及氧化应激，因此适当的抗氧化剂可能是治疗 UC 的有效药物。我们的基于硅（Si）的制剂在摄入后，可在胃肠道中稳定且持续地产生大量氢气。我们通过氢气和抗氧化硫化合物证明，基于 Si 的制剂可缓解葡聚糖硫酸钠诱导的 UC 模型相关的精神症状以及胃肠道症状、炎症和氧化。由于基于 Si 的制剂在治疗小鼠的大脑和大肠 UC 方面是有效的，因此认为它能够抑制 UC 的恶化并维持缓解。
