Institute of Scientific and Industrial Research, Osaka University, Osaka, Japan.
Department of Urology, Osaka University Graduate School of Medicine, Osaka, Japan.
Sci Rep. 2020 Apr 3;10(1):5859. doi: 10.1038/s41598-020-62755-9.
We have developed Si-based agent which can generate a large amount of hydrogen. Si-based agent continues generating hydrogen for more than 24 h by the reaction with water under conditions similar to those in bowels, i.e., pH8.3 and 36 °C, and generates ~400 mL hydrogen. To investigate beneficial effects for diseases associated with oxidative stress, Si-based agent is administered to remnant kidney rats and Parkinson's disease mice. Rats are fed with control or Si-based agent-containing diet for 8 weeks. Si-based agent is found to greatly suppress the development of renal failure and the parameters of oxidative stress. Treatment with Si-based agent in a mouse model of hemi-Parkinson's disease induced by 6-hydroxydopamine attenuated degeneration of dopaminergic neurons and prevented impairment of motor balance and coordination. These findings indicate that the Si-based agent shows renoprotective and neuroprotective effects presumably via suppression of oxidative stress by generation of hydrogen.
我们开发了一种基于硅的试剂，它可以产生大量的氢气。该基于硅的试剂在类似于肠道的条件下（即 pH8.3 和 36°C）与水反应，可以持续产生氢气超过 24 小时，产生约 400 毫升氢气。为了研究与氧化应激相关的疾病的有益效果，我们将基于硅的试剂给残余肾大鼠和帕金森病小鼠使用。大鼠用对照或含基于硅的试剂的饮食喂养 8 周。研究发现，基于硅的试剂极大地抑制了肾衰竭的发展和氧化应激的参数。在由 6-羟多巴胺诱导的半帕金森病小鼠模型中，用基于硅的试剂治疗减轻了多巴胺能神经元的退化，并防止了运动平衡和协调的损害。这些发现表明，该基于硅的试剂通过产生氢气抑制氧化应激显示出肾保护和神经保护作用。
