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利用光子计数探测器 CT 进行肩部和骨盆的超高分辨率成像:一项针对患者的可行性研究。

Ultra-high-resolution imaging of the shoulder and pelvis using photon-counting-detector CT: a feasibility study in patients.

机构信息

Department of Radiology, Mayo Clinic, Rochester, MN, USA.

Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.

出版信息

Eur Radiol. 2022 Oct;32(10):7079-7086. doi: 10.1007/s00330-022-08925-x. Epub 2022 Jun 11.

Abstract

OBJECTIVE

To evaluate ultra-high-resolution (UHR) imaging of large joints using an investigational photon-counting detector (PCD) CT.

MATERIALS AND METHODS

Patients undergoing clinical shoulder or pelvis energy-integrating-detector (EID) CT exam were scanned using the UHR mode of the PCD-CT system. Axial EID-CT images (1-mm sections) and PCD-CT images (0.6-mm sections) were reconstructed using Br62/Br64 and Br76 kernels, respectively. Two musculoskeletal radiologists rated visualization of anatomic structures using a 5-point Likert scale. Wilcoxon rank-sum test was used for statistical analysis of reader scores, and paired t-test was used for comparing bone CT numbers and image noise from PCD-CT and EID-CT.

RESULTS

Thirty-two patients (17 shoulders and 15 pelvis) were prospectively recruited for this feasibility study. Mean age for shoulder exams was 67.3 ± 15.5 years (11 females) and 47.2 ± 15.8 years (11 females) for pelvis exams. The mean volume CT dose index was lower on PCD-CT compared to that on EID-CT (shoulders: 18 mGy vs. 34 mGy, pelvis: 11.6 mGy vs. 16.7 mGy). PCD-CT was rated significantly better than EID-CT (p < 0.001) for anatomic-structure visualization. Trabecular delineation in shoulders (mean score = 4.24 ± 0.73) and femoroacetabular joint visualization in the pelvis (mean score = 3.67 ± 1.03) received the highest scores. PCD-CT demonstrated significant increase in bone CT number (p < 0.001) relative to EID-CT; no significant difference in image noise was found between PCD-CT and EID-CT.

CONCLUSION

The evaluated PCD-CT system provided improved visualization of osseous structures in the shoulders and pelvises at a 31-47% lower radiation dose compared to EID-CT.

KEY POINTS

• A full field-of-view PCD-CT with 0.151 mm × 0.176 mm detector pixel size (isocenter) facilitates bilateral, high-resolution imaging of shoulders and pelvis. • The evaluated investigational PCD-CT system was rated superior by two musculoskeletal radiologists for anatomic structure visualization in shoulders and pelvises despite a 31-47% lower radiation dose compared to EID-CT. • PCD-CT demonstrated significantly higher bone CT number compared to EID-CT, while no significant difference in image noise was observed between PCD-CT and EID-CT despite a 31-47% dose reduction on PCD-CT.

摘要

目的

评估使用新型光子计数探测器(PCD) CT 进行大关节超高分辨率(UHR)成像。

材料与方法

对接受临床肩部或骨盆能量积分探测器(EID) CT 检查的患者进行 UHR 模式 PCD-CT 系统扫描。使用 Br62/Br64 和 Br76 内核分别重建轴向 EID-CT 图像(1mm 节段)和 PCD-CT 图像(0.6mm 节段)。两名肌肉骨骼放射科医生使用 5 分李克特量表对解剖结构的可视化进行评分。使用 Wilcoxon 秩和检验对读者评分进行统计学分析,使用配对 t 检验比较 PCD-CT 和 EID-CT 的骨 CT 值和图像噪声。

结果

前瞻性纳入 32 例(17 例肩部和 15 例骨盆)患者进行此项可行性研究。肩部检查的平均年龄为 67.3±15.5 岁(11 名女性),骨盆检查的平均年龄为 47.2±15.8 岁(11 名女性)。与 EID-CT 相比,PCD-CT 的容积 CT 剂量指数明显更低(肩部:18 mGy 比 34 mGy,骨盆:11.6 mGy 比 16.7 mGy)。PCD-CT 的解剖结构可视化评分明显优于 EID-CT(p<0.001)。肩部的骨小梁勾画(平均评分=4.24±0.73)和骨盆的股髋臼关节可视化(平均评分=3.67±1.03)获得最高分。与 EID-CT 相比,PCD-CT 显著增加了骨 CT 值(p<0.001);PCD-CT 和 EID-CT 的图像噪声无显著差异。

结论

与 EID-CT 相比,评估的 PCD-CT 系统在肩部和骨盆的辐射剂量降低 31%-47%的情况下,改善了骨结构的可视化。

关键点

  • 全视野 PCD-CT 采用 0.151mm×0.176mm 探测器像素大小(等中心),有利于双侧、高分辨率肩部和骨盆成像。

  • 尽管与 EID-CT 相比,辐射剂量降低 31%-47%,但两位肌肉骨骼放射科医生评估的新型 PCD-CT 系统在肩部和骨盆的解剖结构可视化方面的评分更高。

  • 与 EID-CT 相比,PCD-CT 的骨 CT 值显著升高,而 PCD-CT 的图像噪声与 EID-CT 相比无显著差异,尽管 PCD-CT 的剂量降低了 31%-47%。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7628/9474720/62c6eedc3240/nihms-1812000-f0001.jpg

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