Department of Animal Science, Chinese Culture University, Taipei, Taiwan; Graduate Institute of Biotechnology, Chinese Culture University, Taipei, Taiwan.
Department of Preclinical Sciences, Faculty of Medicine and Health Sciences, Universiti Tunku Abdul Rahman, Selangor, Malaysia.
Poult Sci. 2022 Aug;101(8):101950. doi: 10.1016/j.psj.2022.101950. Epub 2022 May 7.
Meat quality and nutritional value hinge on many factors, including fat content in the adipose tissue. In the adipogenesis process, stem cells are first committed to become preadipocytes, followed by preadipocyte differentiation. In the later event, peroxisome proliferator activated receptor gamma (PPARγ) is the gateway through which adipogenic genes are activated. This review focuses on clarifying the effects of signaling transduction on PPARγ that have been experimentally established in the adipogenesis process. Furthermore, microRNA (miRNA) are validated to target the signaling factors and impact adipogenesis are appraised to establish the miRNA-signaling-PPARγ regulatory connection in adipogenesis. As opposed to red meat, chicken is white meat, which is increasingly appreciated for health and environmental reasons. Most works reported on the miRNA-signaling-PPARγ network in adipogenesis used human and other laboratory and farm animal models. We show here that database interrogation and bioinformatics analysis may be applied to extrapolate reported findings to chicken based on evolutionary conservation. Understanding molecular modulation of adipogenesis may contribute to clinical treatment of lipid disorders and obesity in humans, and improved meat quality and commercial value in chicken farming, and possibly in the creation of artificial meat.
肉品质和营养价值取决于许多因素，包括脂肪组织中的脂肪含量。在脂肪生成过程中，干细胞首先被定向成为前脂肪细胞，然后前脂肪细胞分化。在后一事件中，过氧化物酶体增殖物激活受体γ（PPARγ）是激活脂肪生成基因的途径。本综述重点阐明了信号转导对脂肪生成过程中实验证实的 PPARγ 的影响。此外，还评估了 microRNA（miRNA）作为信号因子的靶标，并影响脂肪生成，以建立脂肪生成中 miRNA-信号-PPARγ调控连接。与红肉相比，鸡肉是白肉，由于健康和环境原因，越来越受到人们的喜爱。大多数关于脂肪生成中 miRNA-信号-PPARγ网络的研究工作都使用了人类和其他实验室及农场动物模型。我们在这里表明，可以应用数据库查询和生物信息学分析，根据进化保守性将报告的发现推断到鸡。了解脂肪生成的分子调控可能有助于人类脂质紊乱和肥胖的临床治疗，以及改善鸡肉养殖中的肉质和商业价值，并可能有助于人造肉的研发。
