Shanghai YangZhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), School of Medicine, Tongji University, Shanghai, China.
Center of Clinical Oncology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China; Cancer Institute, Xuzhou Medical University, Xuzhou, Jiangsu, China.
Gene. 2022 Aug 20;836:146662. doi: 10.1016/j.gene.2022.146662. Epub 2022 Jun 8.
Extracellular RNAs (exRNAs) are types of RNAs that present outside of the cells with highly stable features. exRNAs have been shown to play important roles in aiding intercellular communication and regulating cellular processes. In clinical settings, exRNAs have the potential to serve as biomarkers indicating the presence of a disease.Recently, the high-throughput technologies such as RNA sequencing (RNAseq) and microarray have generated abundant exRNA expression data about various diseases. Thus, it is highly desirable to have a comprehensive database for disease-related exRNA transcriptome data detected in diverse body fluids. Here, a total of 88 previously published exRNA transcriptome datasets were collected. We developed a web-accessible database, exRNADisease, which is designed as a central repository for exRNAs from body fluids in human diseases and healthy controls. In the current version, a total of 18,265 samples were collected, which includes 10 body fluids and 78 human disease types. Six different types of RNAs were included (messenger RNAs, circular RNAs, long noncoding RNAs, microRNAs, transfer RNA fragments and PIWI-interacting RNA). Literature is also included to provide the robust evidence about the relationship between exRNAs and diseases. A user-friendly interface was constructed to conveniently search and browse disease-related exRNAs. exRNADisease will become a useful platform to provide genome-wide view of exRNA deregulation in human diseases and help to identify novel biomarkers. Availability and implementation: exRNAdisease can be freely accessible at http://www.origin-gene.cn/database/exRNAdisease/.
细胞外 RNA（exRNA）是存在于细胞外的具有高度稳定性的 RNA 类型。已经证明 exRNA 在辅助细胞间通讯和调节细胞过程中发挥重要作用。在临床环境中，exRNA 有可能作为指示疾病存在的生物标志物。最近，高通量技术如 RNA 测序（RNAseq）和微阵列已经产生了大量关于各种疾病的 exRNA 表达数据。因此，拥有一个包含不同体液中检测到的与疾病相关的 exRNA 转录组数据的综合数据库是非常理想的。在这里，共收集了 88 个先前发表的 exRNA 转录组数据集。我们开发了一个可在线访问的数据库 exRNADisease，该数据库旨在作为人体疾病和健康对照中体液 exRNA 的中央存储库。在当前版本中，共收集了 18265 个样本，包括 10 种体液和 78 种人类疾病类型。包括六种不同类型的 RNA（信使 RNA、环状 RNA、长非编码 RNA、microRNA、转移 RNA 片段和 PIWI 相互作用 RNA）。文献也包括在内，以提供 exRNA 与疾病之间关系的可靠证据。构建了一个用户友好的界面，方便搜索和浏览与疾病相关的 exRNA。exRNADisease 将成为一个有用的平台，提供人类疾病中 exRNA 失调的全基因组视图，并有助于识别新的生物标志物。可用性和实现：exRNAdisease 可在 http://www.origin-gene.cn/database/exRNAdisease/ 上免费访问。
