细胞外 RNA 在不同疾病中的多方面作用。

Multifaceted roles of extracellular RNAs in different diseases.

机构信息

Molecular Medicine and Cancer Therapeutics Lab, Department of Zoology, Faculty of Sciences, University of Central Punjab, Lahore, Pakistan.

Applied Molecular Biology and Biomedicine Lab, Department of Zoology, University of Narowal, Narowal, Pakistan.

出版信息

Mil Med Res. 2022 Aug 11;9(1):43. doi: 10.1186/s40779-022-00405-z.

DOI:10.1186/s40779-022-00405-z

PMID:35948986

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9367134/

Abstract

Extracellular RNAs (exRNAs) are novel circulating factors that can be used as biomarkers in various diseases. Their unique and diverse kinds, as well as their role as biomarkers, make them significant biomarkers. There has been immense work carried out since the discovery of exRNAs in circulation and other biological fluids to catalog and determine whether exRNAs may be utilized as indicators for health and illness. In this review, we aim to understand the current state of exRNAs in relation to various diseases and their potential as biomarkers. We will also review current issues and challenges faced in using exRNAs, with clinical and lab trials, that can be used as viable markers for different diseases.

摘要

细胞外 RNA（exRNA）是新型的循环因子，可作为各种疾病的生物标志物。其独特多样的种类及其作为生物标志物的作用，使它们成为重要的生物标志物。自 exRNA 在循环和其他生物体液中被发现以来，已经开展了大量工作，以对其进行分类并确定 exRNA 是否可用于作为健康和疾病的指标。在这篇综述中，我们旨在了解 exRNA 与各种疾病的关系及其作为生物标志物的潜力。我们还将回顾当前在使用 exRNA 方面面临的问题和挑战，以及可以作为不同疾病的可行标志物的临床和实验室试验。