School of Material and Energy, Yunnan Key Laboratory of Micro/Nano Materials & Technology, Yunnan University, Kunming, 650091, China.
Institute of Forensic Medical, Kunming Medical University, Kunming, 650050, China.
Anal Chim Acta. 2022 Jul 18;1217:340025. doi: 10.1016/j.aca.2022.340025. Epub 2022 May 30.
Detection technology for the determination of drugs, such as ketamine (KT), in sewage is of great significance in drug inspection and criminal investigation. Herein, we propose the utilization of ketamine magnetic molecularly imprinted polymers (FeO@MIPs) as a target molecule identification and concentration container coupled with magnetic glassy carbon electrode (mGCE) for KT detection in sewage. Molecular simulations were employed to evaluate the most suitable monomer and ratio of functional monomer to template. FeO@MIPs were prepared using microwave-assisted synthesis and possessed a "shell-core" structure with good recognition ability, superior adsorption capacity and fast kinetics toward KT. Additionally, a novel imprinted electrochemical sensor was constructed based on the magnetism of FeO@MIPs for efficient monitoring of low concentrations of KT. The morphology and properties of FeO@MIPs/mGCE were effectively characterized by element mapping, transmission electron microscopy, cyclic voltammetry and square wave voltammetry. KT detection was performed by square wave voltammetry within the range of 1.0 × 10 and 4.0 × 10 mol L, and the limit of detection was 8.0 × 10 mol L. Furthermore, FeO@MIPs/mGCE was successfully tested for KT determination in domestic sewage samples.
用于检测污水中药物（如氯胺酮 (KT)）的检测技术在药物检测和刑事调查中具有重要意义。在此，我们提出将氯胺酮磁性分子印迹聚合物 (FeO@MIPs) 用作目标分子识别和浓缩容器，并与磁性玻碳电极 (mGCE) 结合，用于检测污水中的 KT。采用分子模拟评估最适合的单体和功能单体与模板的比例。采用微波辅助合成制备了 FeO@MIPs，具有良好的识别能力、优异的吸附能力和对 KT 的快速动力学。此外，基于 FeO@MIPs 的磁性构建了一种新型印迹电化学传感器，用于高效监测低浓度的 KT。通过元素映射、透射电子显微镜、循环伏安法和方波伏安法有效地对 FeO@MIPs/mGCE 的形态和性质进行了表征。通过方波伏安法在 1.0×10 和 4.0×10 mol L 的范围内进行 KT 检测，检测限为 8.0×10 mol L。此外，成功地使用 FeO@MIPs/mGCE 对生活污水样品中的 KT 进行了测定。
