Department of Neurocritical Care, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510120, China.
Department of Scientific Affairs, Hugobiotech Co., Ltd., Beijing, People's Republic of China.
BMC Neurol. 2022 Jun 11;22(1):217. doi: 10.1186/s12883-022-02733-y.
We report a rare case of Gardnerella vaginalis found in the cerebrospinal fluid of a young boy.
A 14-year-old boy was admitted to hospital with headache, vomiting, fever, drowsiness and positive meningeal irritation signs on examination. Cerebrospinal fluid (CSF) shows white blood cell and protein were elevated, and glucose was low. Traditional aerobic and anaerobic culture of CSF did not grow any organisms. However, metagenomic next-generation sequencing (mNGS) reveals G. vaginalis in his CSF. The patient was diagnosed with purulent meningitis, and treated with intravenous meropenem and linezolid for a week, followed by oral administration of amoxicillin for two weeks. He recovered without sequelae.
Purulent meningitis caused by Gardnerella vaginalis is extremely rare. Metagenomic next-generation sequencing of CSF should be highlighted for early diagnosis. With effective antibiotic treatment, the prognosis was excellent.
我们报告了一例罕见的加德纳菌阴道病发生于年轻男性患者的脑脊液中。
一名 14 岁男孩因头痛、呕吐、发热、嗜睡和脑膜刺激征阳性而入院。脑脊液（CSF）检查示白细胞和蛋白升高，葡萄糖降低。传统的 CSF 需氧和厌氧培养均未发现任何病原体。然而，基于宏基因组下一代测序（mNGS）在其 CSF 中发现了加德纳菌阴道病。该患者被诊断为化脓性脑膜炎，给予静脉注射美罗培南和利奈唑胺治疗 1 周，随后口服阿莫西林治疗 2 周。患者最终痊愈，无后遗症。
加德纳菌阴道病引起的化脓性脑膜炎极为罕见。CSF 的宏基因组下一代测序应作为早期诊断的重点。经有效抗生素治疗，预后良好。
