Inuo Chisato, Okazaki Fumiko, Shiraki Rie, Tanaka Yutaka, Momma Keiko, Kondo Yasuto, Narita Hiroshi
Department of Allergy, Kanagawa Children's Medical Center, 2-138-4 Mutsukawa, Minami-ku, Yokohama, Kanagawa, 232-8555, Japan.
Department of Food Science and Human Nutrition Faculty of Agriculture, Ryukoku University, 1-5 Yokotani, Seta Oe-cho, Otsu, Shiga, 520-2194, Japan.
Allergy Asthma Clin Immunol. 2022 Jun 11;18(1):49. doi: 10.1186/s13223-022-00692-0.
The Rosaceae family includes fruits, such as peach, apple, Japanese apricot, cherry (Prunoideae subfamily), and strawberry (Rosoideae subfamily). The allergens responsible for Rosaceae fruit allergies have been reported to include Bet v 1 and profilin, which mainly cause oral symptoms, and lipid transfer protein (LTP). Recently, gibberellin-regulated protein (GRP) has been identified as an allergen that induces generalized symptoms in peach-, orange-, and plum-related allergies. Most patients with food allergies induced by GRP show allergic symptoms accompanied by cofactors, such as exercise or drugs. To date, there are very few reports of generalized symptoms induced by strawberry.
We evaluated the reactivity of strawberry GRP in a 15-year-old boy who was confirmed to have generalized symptoms induced by strawberry with exercise using an oral food challenge test (OFCT). The patient's serum exhibited a strong positive reaction to strawberry GRP but not to peach GRP or peach LTP. The patient's basophils reacted to strawberry and peach GRP but not to peach LTP.
Strawberry GRP may be a causative component for strawberry with exercise-induced generalized symptoms in this patient. This is the first study to investigate the role of GRP in strawberry with cofactor-induced allergic symptoms. Further epidemiological and clinical researches are necessary to improve diagnostic and therapeutic approaches for patients with strawberry allergy.
蔷薇科包括多种水果，如桃、苹果、杏、樱桃（李亚科）和草莓（蔷薇亚科）。据报道，引起蔷薇科水果过敏的过敏原包括主要导致口腔症状的Bet v 1和肌动蛋白结合蛋白，以及脂质转移蛋白（LTP）。最近，赤霉素调节蛋白（GRP）已被确定为一种过敏原，可在桃、橙和李相关过敏中引发全身性症状。大多数由GRP引起食物过敏的患者表现出伴有运动或药物等辅助因素的过敏症状。迄今为止，关于草莓引起全身性症状的报道非常少。
我们通过口服食物激发试验（OFCT）评估了一名15岁男孩体内草莓GRP的反应性，该男孩被证实运动后食用草莓会引发全身性症状。患者血清对草莓GRP呈强阳性反应，但对桃GRP或桃LTP无反应。患者的嗜碱性粒细胞对草莓和桃GRP有反应，但对桃LTP无反应。
草莓GRP可能是该患者运动后食用草莓引发全身性症状的致病成分。这是第一项研究GRP在有辅助因素诱导的草莓过敏症状中作用的研究。有必要进行进一步的流行病学和临床研究，以改进草莓过敏患者的诊断和治疗方法。
