Department of Pediatrics, Dokkyo Medical University, Tochigi, Japan.
Department of Pediatrics, Dokkyo Medical University, Tochigi, Japan,
Int Arch Allergy Immunol. 2020;181(3):183-190. doi: 10.1159/000504367. Epub 2019 Dec 10.
Component-resolved diagnostics is used to diagnose food allergies. However, few reports have evaluated the severity of peach fruit allergy using peach allergen components, including Pru p 7.
This study aimed to predict peach fruit allergy severity based on the presence of specific IgE (sIgE) antibodies (Abs) to peach allergenic components.
Twenty-seven patients with peach fruit allergy were enrolled and classified into two groups: the local reaction (LR) group, including 12 patients with only oral or throat mucosal symptoms, and the systemic reaction (SR) group, including 15 patients, 10 of whom experienced anaphylaxis. Serum sIgE Abs against crude peach extract - Pru p 1, 2, 3, 4, and 7 - and tree pollen were measured.
sIgE Ab titers of Pru p 1 and 4 and alder pollen in the LR group were significantly higher than those in the SR group. sIgE against Pru p 7 was significantly higher in the SR group than in the LR group. The frequencies of sIgE Abs against Pru p 1, 4, and 7 in the LR group were 91.7, 66.7, and 16.7%, respectively, while in the SR group these were 80, 20, and 60%. Sensitization to Pru p 2 and 3 was detected but limited in all patients.
These findings suggest that sensitization to Pru p 1 and Pru p 4 is associated with local symptoms, and sensitization to Pru p 7 is associated with SR and anaphylaxis. To predict the severity of peach fruit allergy, it is useful to assess sIgE Ab reactions combining Pru p 1, 4, and 7.
成分分辨诊断用于诊断食物过敏。然而，很少有报道使用桃过敏原成分评估桃果实过敏的严重程度，包括 Pru p 7。
本研究旨在根据对桃过敏原成分的特异性 IgE（sIgE）抗体（Abs）的存在来预测桃果实过敏的严重程度。
共纳入 27 例桃过敏患者，并分为两组：局部反应（LR）组，包括 12 例仅有口腔或咽喉黏膜症状的患者；全身反应（SR）组，包括 15 例患者，其中 10 例发生过敏反应。检测血清 sIgE Abs 对粗桃提取物-Pru p 1、2、3、4 和 7-和树花粉的反应。
LR 组 Pru p 1 和 4 的 sIgE Ab 滴度以及桤木花粉明显高于 SR 组。SR 组 Pru p 7 的 sIgE 明显高于 LR 组。LR 组 sIgE Abs 对 Pru p 1、4 和 7 的阳性率分别为 91.7%、66.7%和 16.7%，而在 SR 组分别为 80%、20%和 60%。在所有患者中均检测到对 Pru p 2 和 3 的致敏，但有限。
这些发现表明，对 Pru p 1 和 Pru p 4 的致敏与局部症状有关，而对 Pru p 7 的致敏与 SR 和过敏反应有关。为了预测桃果实过敏的严重程度，评估结合 Pru p 1、4 和 7 的 sIgE Ab 反应是有用的。
