Menzies Health Institute Queensland, Griffith University, Gold Coast Campus, QLD, 4222, Australia.
Exercise Science, School of Health Sciences and Social Work, Griffith University, Gold Coast Campus, QLD, 4222, Australia.
Calcif Tissue Int. 2022 Sep;111(3):256-266. doi: 10.1007/s00223-022-00991-z. Epub 2022 Jun 12.
To compare the effects of high-intensity resistance and impact training (HiRIT) to low-intensity, Pilates-based exercise (LiPBE) on proximal femur geometry and explore the influence of antiresorptive medication on those effects. Postmenopausal women with low bone mass, on or off antiresorptive bone medications were randomly allocated, stratified on medication intake, to eight months of twice-weekly, supervised HiRIT (Onero™) or LiPBE (Buff Bones®). 3D hip software was used to analyse proximal femur DXA scans. Outcomes included femoral neck (FN) and total hip (TH), volumetric (e.g. vBMC, vBMD) and geometric (e.g. cortical thickness, cross-sectional area [CSA], section modulus [Z]) indices of bone strength. Data were analysed using analysis of variance. Scans of 102 women were examined: LiPBE, 43; HiRIT, 37; LiPBE-med, 11; HiRIT-med, 11. HiRIT improved TH trabecular vBMC and vBMD (3.1 ± 1.1% versus - 1.2 ± 1.2%, p = 0.008; and 1.5 ± 1.0% versus - 1.6 ± 1.2%, p = 0.042, respectively) and FN and TH total vBMC (2.0 ± 0.8% versus - 0.2 ± 0.7%, p = 0.032; and 0.7 ± 0.4% versus - 0.8 ± 0.6%, p = 0.032, respectively), compared to losses in LiPBE. HiRIT also increased Z while LiPBE did not (p = 0.035). The combination of HiRIT and medication achieved greater improvements in FN total and trabecular vBMD, total BMC, CSA and Z than HiRIT alone. HiRIT improved geometric parameters of proximal femur strength, while LiPBE exercise was largely ineffective. Medication may enhance some HiRIT effects. Findings suggest reduced hip fracture risk in response to HiRIT.Trial registration number ACTRN12617001511325.
比较高强度阻力和冲击训练（HiRIT）与低强度、基于普拉提的运动（LiPBE）对股骨近端几何形状的影响，并探讨抗吸收药物对这些影响的影响。患有低骨量的绝经后妇女，无论是否服用抗吸收骨药物，均按药物摄入分层，随机分配至 8 个月、每周两次、监督的 HiRIT（Onero™）或 LiPBE（Buff Bones®）。使用髋关节 3D 软件分析 DXA 扫描的股骨近端。结果包括股骨颈（FN）和全髋（TH）、体积（如 vBMC、vBMD）和几何（如皮质厚度、横截面积[CSA]、截面模量[Z]）骨强度指数。使用方差分析进行数据分析。共检查了 102 名女性的扫描结果：LiPBE 43 例，HiRIT 37 例，LiPBE 药物治疗 11 例，HiRIT 药物治疗 11 例。HiRIT 改善了 TH 小梁 vBMC 和 vBMD（3.1±1.1%比-1.2±1.2%，p=0.008；和 1.5±1.0%比-1.6±1.2%，p=0.042）和 FN 和 TH 总 vBMC（2.0±0.8%比-0.2±0.7%，p=0.032；和 0.7±0.4%比-0.8±0.6%，p=0.032），而 LiPBE 则导致损失。HiRIT 还增加了 Z，而 LiPBE 没有（p=0.035）。与 HiRIT 单独治疗相比，HiRIT 和药物联合治疗可使 FN 总和小梁 vBMD、总 BMC、CSA 和 Z 获得更大的改善。HiRIT 改善了股骨近端强度的几何参数，而 LiPBE 运动的效果则不大。药物可能会增强某些 HiRIT 效果。研究结果表明，HiRIT 可降低髋部骨折风险。试验注册号：ACTRN12617001511325。
