Department of Pain, The First Medical Center of People's Liberation Army (PLA) General Hospital, Beijing, China.
Department of Anesthesiology, People's Liberation Army (PLA) General Hospital of Hainan Hospital, Sanya, Hainan, China.
Front Endocrinol (Lausanne). 2023 Oct 23;14:1154927. doi: 10.3389/fendo.2023.1154927. eCollection 2023.
To explore the risk factors of osteoporosis in postmenopausal women in China.
This study collected all patient data from January 2014 to December 2015. Basic information and questionnaires were collected from 524 postmenopausal women in Sanya and Hainan Province. The questionnaire was administered to the enrolled participants by endocrinologists. Biochemical parameters were measured using fasting blood samples, and bone density was measured by dual energy X-ray absorptiometry at the department of radiology of Hainan hospital, PLA General Hospital. Participants with an R-value of ≤-2.5 were diagnosed with osteoporosis. After deleting missing values for each factor, 334 participants were divided into the osteoporosis (n=35) and non-osteoporosis (n=299) groups according to the R-values.
The participants had a median age of 60.8 years (range: 44-94 years). Among the 334 postmenopausal women included in this study, 35 (10.5%) were diagnosed with osteoporosis. Univariate analysis showed statistically significant differences in age, BMI, type of work, alkaline phosphatase, years of smoking, blood calcium levels, kyphosis, fracture, and asthma between the two groups (P<0.05). In addition, multivariate logistic analysis showed that age (odds ratio [OR]: 1.185, 95% confidence interval [CI]: 1.085-1.293, P<0.001) and kyphosis times (OR:1.468, 95% CI: 1.076-2.001, P=0.015) were positively correlated with postmenopausal osteoporosis, whereas BMI (OR: 0.717, 95% CI: 0.617-0.832, P<0.001), blood calcium levels (OR: 0.920, 95% CI: 0.854-0.991, P=0.027), vitamin D levels (OR: 0.787, 95% CI: 0.674-0.918, P=0.002), and outdoor activity time (OR: 0.556, 95% CI: 0.338-0.915, P=0.021) were negatively correlated with postmenopausal osteoporosis.
Low BMI, blood calcium and vitamin D levels, kyphosis time, and outdoor activity time are independent risk factors for osteoporosis in postmenopausal women.
探讨中国绝经后妇女骨质疏松的危险因素。
本研究收集了 2014 年 1 月至 2015 年 12 月期间的所有患者数据。共收集了三亚和海南省的 524 名绝经后妇女的基本信息和问卷，由内分泌科医生向入组参与者发放问卷。使用空腹血样测量生化参数，并在解放军总医院海南医院放射科使用双能 X 射线吸收仪测量骨密度。R 值≤-2.5 的患者被诊断为骨质疏松症。在删除每个因素的缺失值后，根据 R 值将 334 名参与者分为骨质疏松症（n=35）和非骨质疏松症（n=299）组。
参与者的中位年龄为 60.8 岁（范围：44-94 岁）。在本研究中纳入的 334 名绝经后妇女中，有 35 名（10.5%）被诊断为骨质疏松症。单因素分析显示，两组在年龄、BMI、工作类型、碱性磷酸酶、吸烟年限、血钙水平、后凸畸形、骨折和哮喘方面存在统计学差异（P<0.05）。此外，多因素 logistic 分析显示，年龄（比值比[OR]：1.185，95%置信区间[CI]：1.085-1.293，P<0.001）和后凸畸形次数（OR：1.468，95%CI：1.076-2.001，P=0.015）与绝经后骨质疏松呈正相关，而 BMI（OR：0.717，95%CI：0.617-0.832，P<0.001）、血钙水平（OR：0.920，95%CI：0.854-0.991，P=0.027）、维生素 D 水平（OR：0.787，95%CI：0.674-0.918，P=0.002）和户外活动时间（OR：0.556，95%CI：0.338-0.915，P=0.021）与绝经后骨质疏松呈负相关。
低 BMI、血钙和维生素 D 水平、后凸畸形时间和户外活动时间是绝经后妇女骨质疏松的独立危险因素。
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