Experimental and Clinical Pharmacopsychology, Department of Psychiatry, Psychotherapy, and Psychosomatics, Psychiatric University Hospital Zurich, University of Zurich, Switzerland; Neuroscience Center Zurich, University of Zurich and Swiss Federal Institute of Technology Zurich, Switzerland.
Experimental and Clinical Pharmacopsychology, Department of Psychiatry, Psychotherapy, and Psychosomatics, Psychiatric University Hospital Zurich, University of Zurich, Switzerland; Neuroscience Center Zurich, University of Zurich and Swiss Federal Institute of Technology Zurich, Switzerland.
Neurosci Biobehav Rev. 2022 Aug;139:104729. doi: 10.1016/j.neubiorev.2022.104729. Epub 2022 Jun 9.
The serotonergic system is involved in diverse cognitive functions including memory. Of particular importance to daily life are declarative memories that contain information about personal experiences, general facts, and events. Several psychiatric or neurological diseases, such as depression, attention-deficit-hyperactivity disorder (ADHD), and dementia, show alterations in serotonergic signalling and attendant memory disorders. Nevertheless, understanding serotonergic neurotransmission and its influence on memory remained a challenge until today. In this systematic review, we summarize recent psychopharmacological studies in animals and humans from a psychological memory perspective, in consideration of task-specific requirements. This approach has the advantage that comparisons between serotonin (5-HT)-related neurochemical mechanisms and manipulations are each addressing specific mnemonic circuits. We conclude that applications of the same 5-HT-related treatments can differentially affect unrelated tasks of declarative memories. Moreover, the analysis of specific mnemonic phases (e.g., encoding vs. consolidation) reveals opposing impacts of increased or decreased 5-HT tones, with low 5-HT supporting spatial encoding but impairing the consolidation of objects and verbal memories. Promising targets for protein synthesis-dependent consolidation enhancements include 5-HT receptor agonists and 5-HT receptor antagonists, with the latter being of special interest for the treatment of age-related decline. Further implications are pointed out as base for the development of novel therapeutic targets for memory impairment of neuropsychiatric disorders.
血清素能系统参与多种认知功能，包括记忆。对日常生活特别重要的是陈述性记忆，它包含关于个人经历、一般事实和事件的信息。几种精神或神经疾病，如抑郁症、注意缺陷多动障碍（ADHD）和痴呆，表现出血清素信号传递的改变和随之而来的记忆障碍。然而，直到今天，理解血清素能神经传递及其对记忆的影响仍然是一个挑战。在这个系统综述中，我们从心理学记忆的角度总结了最近关于动物和人类的精神药理学研究，考虑到特定任务的要求。这种方法的优点是，对与 5-HT 相关的神经化学机制和操作的比较，分别针对特定的记忆回路。我们得出结论，相同的 5-HT 相关治疗方法的应用可以对陈述性记忆的不相关任务产生不同的影响。此外，对特定记忆阶段（例如，编码与巩固）的分析揭示了增加或减少 5-HT 音调的相反影响，低 5-HT 支持空间编码，但损害物体和言语记忆的巩固。对蛋白质合成依赖性巩固增强有希望的靶标包括 5-HT 受体激动剂和 5-HT 受体拮抗剂，后者对于治疗与年龄相关的衰退特别有意义。进一步的影响被指出作为为神经精神障碍的记忆障碍开发新的治疗靶标的基础。
