The Laboratory of Medical Mycology, Jining No. 1 People's Hospital, Jining, Shandong 272000, China.
Institute of Immunology and Molecular Medicine, Basic Medical School, Jining Medical University, Jining, Shandong 272067, China.
Photodiagnosis Photodyn Ther. 2022 Sep;39:102952. doi: 10.1016/j.pdpdt.2022.102952. Epub 2022 Jun 9.
Cutaneous infectious granulomas are mainly caused by fungi and bacteria. Antibiotics are the primary therapeutic choices for these diseases, but drug-resistant pathogens have become increasingly prevalent. Thus, there is a need to explore novel approaches to treat cutaneous infectious granulomas. Photodynamic therapy (PDT) is widely used as a treatment for various kinds of skin diseases, and evidence has been accumulating that PDT is also effective for the treatment of cutaneous infectious granulomas. In this narrative review, we sought to summarize the recent literature concerning the applications and mechanisms of PDT in the treatment of cutaneous infectious granulomas. Clinical and basic research has demonstrated that PDT is an effective approach in treating fungal infections such as sporotrichosis and chromoblastomycosis. In addition, PDT is also used to treat atypical mycobacterial infections such as Mycobacterium marinum. PDT can significantly shorten the duration of antibiotics treatment, resulting in diminishment of adverse effects. The potential mechanisms of PDT are to kill the pathogens directly or elicit modulatory effects on the immune microenvironments. We conclude that PDT is a promising therapeutic choice for the treatment of cutaneous infectious granulomas.
皮肤感染性肉芽肿主要由真菌和细菌引起。抗生素是治疗这些疾病的主要选择，但耐药病原体越来越普遍。因此，需要探索治疗皮肤感染性肉芽肿的新方法。光动力疗法 (PDT) 被广泛用于治疗各种皮肤疾病，有证据表明 PDT 对治疗皮肤感染性肉芽肿也有效。在这篇叙述性综述中，我们试图总结 PDT 在治疗皮肤感染性肉芽肿方面的应用和机制的最新文献。临床和基础研究表明，PDT 是治疗孢子丝菌病和着色芽生菌病等真菌感染的有效方法。此外，PDT 也用于治疗非典型分枝杆菌感染，如海分枝杆菌感染。PDT 可显著缩短抗生素治疗的持续时间，减少不良反应。PDT 的潜在机制是直接杀死病原体或对免疫微环境产生调节作用。我们得出结论，PDT 是治疗皮肤感染性肉芽肿的一种很有前途的治疗选择。
